RecruitingNCT05498974

China Diabetes Type 1 Study (CD1S) by China Alliance for Type 1 Diabetes

Sponsor

Second Xiangya Hospital of Central South University

Enrollment

20,000 participants

Start Date

Jan 1, 2022

Study Type

OBSERVATIONAL

Conditions

Diabetes Type1diabetes

Summary

The aim of the China Diabetes Type 1 Study (CD1S) is to conduct a nationwide type 1 diabetes (T1D) registry study in patients with T1D and in pediatric adolescent patients with diabetes who had an age of onset \<= 20 years. CD1S compromises a retrospective study enrolling inpatients hospitalized from Jan 1st, 2016 to Dec 31, 2021, and a prospective study beginning from the year 2022.

Eligibility

Inclusion Criteria4

\. Patients with type 1 diabetes mellitus of any duration; meeting criteria (1) or any of (2) or any of (3)
Clinical diagnosis of type 1 diabetes by a specialist
Age at onset \< 15 years; no overweight or obesity at onset; previous diabetic ketoacidosis; highest random C-peptide \< 200 pmol/L
Initiation and continuation of insulin therapy (except pancreatic or islet transplantation) after diagnosis; positive islet autoantibodies Or 2. Children and adolescents with diabetes mellitus at age of onset \<= 20 years, regardless of type and duration of disease.

Exclusion Criteria3

For enrolment of patients with T1D, exclusion was made if any of the following criteria were met (not applicable to those with onset under 20 years of age)
No insulin dependence for at least 6 months after diagnosis of diabetes mellitus.
No DKA for 1 month off insulin for those with a history of diabetes \> 1 year. ③ C-peptide \> 800 pmol/L at any time point.

Interventions

OTHERStandard type 1 diabetes management model constructed by China Alliance for Type 1 Diabetes in each center

Standard type 1 diabetes management model constructed by China Alliance for Type 1 Diabetes in each center

Locations(11)

Gansu Provincial People's Hospital

Lanzhou, Gansu, China

Shenzhen Second People's Hospital

Shenzhen, Guangdong, China

Hainan General Hospital

Haikou, Hainan, China

the First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China

The First Affiliated Hospital of Henan University of Science and Technology

Luoyang, Henan, China

The Second Xiangya Hospital, Central South University

Changsha, Hunan, China

The First Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China

Heji Hospital Affiliated to Changzhi Medical College

Changzhi, Shanxi, China

The First Affiliated Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, China

The First People's Hospital of Yunnan

Kunming, Yunnan, China

Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, China

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