RecruitingPhase 2NCT05499702

The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction

Sponsor

Adrian Vella

Enrollment

20 participants

Start Date

Dec 15, 2022

Study Type

INTERVENTIONAL

Conditions

Type2diabetes

Summary

Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentrations. Caloric restriction also improves hepatic steatosis and lowers fasting AA. These changes may represent restoration of glucagon's hepatic actions. This experiment will determine whether caloric restriction improves glucagon's actions on hepatic amino acid, carbohydrate and lipid metabolism in T2DM in comparison to a baseline experiment performed separately in people with T2DM.

Eligibility

Min Age: 25 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how the hormone glucagon affects fat storage in the liver in people with type 2 diabetes, particularly after they cut back on calories. Understanding this could help develop better treatments for fatty liver disease in people with diabetes. **You may be eligible if...** - You have type 2 diabetes managed by diet alone or oral medications - Your BMI is 28 or above - Your weight has been stable recently **You may NOT be eligible if...** - You have had upper abdominal surgery (like gastric banding or stomach procedures) - You have active cancer or a serious systemic illness - You have complications from diabetes affecting your heart or nerves - You have metal implants or claustrophobia (MRI required) - You drink more than 2 alcoholic beverages per day Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCaloric Restriction

Subjects will be instructed to consume a diet of 900 kcal daily using meals derived from "Nutritional Guidelines after Bariatric Surgery". Compliance will be monitored by weekly meetings with the dietician using an electronic record of food intake

DRUGHyperglycemic clamp

Hyperglycemic clamp to measure the effect of glucagon on hepatic metabolism