RecruitingPhase 2NCT05501704

ETHAN - ET for Male BC

ETHAN: A Phase II Study Comparing Different Endocrine THerapies for mAle Breast caNcer


Sponsor

Jose Pablo Leone

Enrollment

60 participants

Start Date

Oct 11, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This research study is looking to see how well male breast cancer responds to preoperative treatment with endocrine therapy and which endocrine therapy regimen is the most effective treatment for male breast cancer. The drugs used in this study are: * Tamoxifen * Anastrozole * Degarelix * Abemaciclib


Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study (ETHAN) is looking at hormone therapy as a treatment for men with breast cancer. Male breast cancer is rare, and this trial aims to better understand how well hormone-blocking therapy works in men before surgery. **You may be eligible if...** - You are a man 18 or older with invasive breast cancer (stage I, II, or III) - You have not yet had surgery to remove the tumor - Your cancer is hormone receptor-positive (responds to estrogen or progesterone) and HER2-negative **You may NOT be eligible if...** - Your cancer is HER2-positive or hormone receptor-negative - You have already had surgery - Your cancer is stage IV (has spread to other parts of the body) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGTamoxifen

Taken orally

DRUGAnastrozole

Taken orally

DRUGDegarelix

Subcutaneous (under the skin) injection

DRUGAbemaciclib

Taken orally


Locations(8)

Georgetown University Medical Center

Washington D.C., District of Columbia, United States

Dana Farber Cancer Institute

Boston, Massachusetts, United States

Mayo Clinic

Rochester, Minnesota, United States

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, United States

University of Pennsylvania, Abramson Cancer Center

Philadelphia, Pennsylvania, United States

University of Pittsburgh Cancer Institute

Pittsburgh, Pennsylvania, United States

Vanderbilt Cancer Center

Nashville, Tennessee, United States

M. D. Anderson Cancer Center at University of Texas

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05501704


Related Trials