Specific Dietary Pattern for Crohn's Disease Patients Following Surgery
Effectiveness and Pathogenesis of Specific Dietary Pattern in Maintaining Remission Among Crohn's Disease(CD) Patients Following Surgery
Second Affiliated Hospital, School of Medicine, Zhejiang University
35 participants
Sep 17, 2022
INTERVENTIONAL
Conditions
Summary
Over the past 10 years, there are a large number of dietary treatments related to the CD, such as specific carbohydrate diet, low Fermentable Oligo-, Di-, Mono-saccharides And Polyols (FODMAP) diet, and allergen-free foods. But there is no consistent conclusion or convincing evidence about the effectiveness. Through the long-term clinical experience observation, we find most of the CD patients can get stable remission by removing refined food and intolerance food.This project aims at developing a new dietary therapy suitable for Chinese patients.
Eligibility
Inclusion Criteria3
- Diagnose CD according to endoscopy, histology and imaging;
- Bowel resection for CD
- Oral nutritional preparations or food can be given after surgery
Exclusion Criteria17
- Plan operation within 5 weeks after surgery;
- Presence of an ileostomy or colostomy
- Complete bowel obstruction or fibrous stricture
- Pregnancy or breastfeeding;
- Plan to use biological agents within 5 weeks after surgery;
- Plan to use corticosteroids or prednisone greater than 20 mg per day or equivalent doses of drugs to maintain remission within 5 weeks after surgery;
- Plan to use probiotics or prebiotics for more than 1 week after surgery;
- Antibiotics are used for more than 2 weeks after surgery;
- Hypersensitivity to known components of enteral nutrition;
- BMI less than 14 or greater than 28 kg/m2;
- Celiac disease;
- Complicated with other autoimmune diseases such as diabetes or rheumatic disease, autoimmune liver disease, psoriasis;
- Mental illness;
- Malignant tumors
- Those who are not suitable for body composition analysis (such as pacemakers and metal objects in the body)
- Participating in other clinical trials
- The researcher believes that others are not suitable to participate in this study.
Interventions
Reprocessed and intolerant foods were removed from the dietary pattern, and the food were cooked at home for experimental subjects.
All energy and nutrients are obtained from exclusive enteral nutrition.
Locations(1)
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NCT05502965