RecruitingPhase 4NCT07310095

A Study to Evaluate the Efficacy of Guselkumab in Chinese Participants With Crohn's Disease (CD)

Efficacy of Guselkumab in Chinese Participants With Crohn's Disease Following Loss of Response to Ustekinumab


Sponsor

Xian-Janssen Pharmaceutical Ltd.

Enrollment

78 participants

Start Date

Dec 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate how well guselkumab works in participants with Crohn's disease (CD; a long-term condition causing severe inflammation of the intestinal tract) who no longer respond to treatment with ustekinumab.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates whether guselkumab (a medication that blocks inflammation) can help control Crohn's disease — a condition causing chronic inflammation in the digestive tract — in Chinese patients who have not responded well to a previous biologic drug called ustekinumab. **You may be eligible if...** - You have a confirmed diagnosis of active Crohn's disease - Your disease is currently active, with significant abdominal pain or frequent loose stools - You previously received ustekinumab but did not have an adequate response **You may NOT be eligible if...** - Your Crohn's disease is currently in remission - You have not previously been treated with ustekinumab as per the study protocol - You have certain infections or other conditions that exclude participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGGuselkumab (GUS)

Guselkumab will be administered intravenously or by subcutaneous injection.


Locations(5)

The First Affiliated Hospital Sun Yat sen University

Guangzhou, China

The Sixth Affiliated Hospital Sun Yat sen University

Guangzhou, China

Sir Run Run Shaw Hospital Zhejiang University School of Medicine

Hangzhou, China

The First Affiliated Hospital of Anhui Medical University

Hefei, China

Ruijin Hospital

Shanghai, China

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NCT07310095


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