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RecruitingPhase 1NCT05504837

A Study Assessing KB407 for the Treatment of Cystic Fibrosis

KB407-02 A Phase 1 Study of Inhaled KB407, a Replication-Defective, Non-Integrating Vector Expressing Human Cystic Fibrosis Transmembrane Conductance Regulator, for the Treatment of Cystic Fibrosis

Sponsor

Krystal Biotech, Inc.

Enrollment

20 participants

Start Date

Jun 30, 2023

Study Type

INTERVENTIONAL

Conditions

Cystic Fibrosis

Summary

This study will evaluate safety and tolerability of ascending doses of nebulized KB407 in adults with cystic fibrosis.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called KB407 (Nebulization) for people with cystic fibrosis. The study is currently recruiting participants at 6 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALKB407 (Nebulization)

Nebulized solution of KB407, a replication-defective HSV-1 expressing full length human CFTR

Locations(6)

University of Florida, Gainesville

Gainesville, Florida, United States

St. Lukes CF Center of Idaho

Boise, Idaho, United States

The Cystic Fibrosis Institute

Northfield, Illinois, United States

New York Medical College/ Boston Children's Health Physicians

Hawthorne, New York, United States

Northwell Health Physicians

New York, New York, United States

Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, United States

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NCT05504837

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