Efficacy of Immunosuppressive Therapy for IgA Nephropathy With Stage 3 or 4 CKD

This study looks at whether immunosuppressive therapy (medications that calm the immune system) can help patients with IgA nephropathy — a kidney disease where the immune system mistakenly damages the kidneys — who already have significant kidney decline. Standard blood pressure medications (RAS blockers) alone may not be enough for these patients. **You may be eligible if...** - You have been diagnosed with IgA nephropathy confirmed by kidney biopsy - You are losing protein in the urine (1.0 g or more per day) despite being on maximum doses of blood pressure medications (RAS blockers) - Your kidney filtration rate (eGFR) is between 15 and 60 mL/min — indicating moderate to severe kidney impairment **You may NOT be eligible if...** - You have a specific medical reason that requires immune-suppressing therapy (beyond this study) or a reason you cannot take it - You have severe uncontrolled infections - You have another condition affecting the kidneys besides IgA nephropathy - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.