RecruitingNCT05513716

Molecular Characterisation of Colorectal Cancer Peritoneal Metastases

Molecular Characterisation of Colorectal Cancer Peritoneal Metastases: Genomic and Transcriptomic Analysis With Correlation of Clinical Outcomes


Sponsor

The Christie NHS Foundation Trust

Enrollment

200 participants

Start Date

Feb 4, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This project aims to characterise the tumour cell and tumour microenvironment of colorectal cancer peritoneal metastases, understand molecular changes leading to colorectal peritoneal metastasis, identify potential biomarkers and novel treatment strategies.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study analyzes the molecular characteristics — the genetic and biological makeup — of colorectal cancer that has spread to the lining of the abdomen (called peritoneal metastases). By comparing samples from the original colon tumor and the spread, researchers hope to find new targets for treatment. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with colorectal cancer that has spread to the peritoneum (abdominal lining) - You have undergone cytoreductive surgery (surgery to remove as much cancer as possible) at the Christie hospital - Archived tumor tissue from both the original tumor and the spread is available for analysis **You may NOT be eligible if...** - You have not had cytoreductive surgery at the Christie - Archival tumor tissue is not available - There are no other exclusion criteria listed for this observational tissue study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERRetrospective tissue sample analysis

Archival formalin-fixed, paraffin-embedded (FFPE) tumour tissue from colorectal cancer peritoneal metastasis and paired primary tumours, where available - taken as standard care


Locations(1)

Christie Hospital NHS Foundation Trust

Manchester, United Kingdom

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NCT05513716


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