Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform

This study is collecting tumor tissue samples from patients with various cancers to develop and train a new type of test called a "live tumor drug sensitivity assay" — essentially growing small pieces of a patient's actual tumor in the lab and testing which drugs kill it best, helping personalize cancer treatment. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with one of these cancers: bladder, kidney, colorectal, head and neck, liver, lung, skin melanoma, uterine (endometrial) cancer, or any solid tumor that may be treated with immunotherapy (checkpoint inhibitors) - Your cancer is advanced, recurrent, or metastatic (or stage III melanoma eligible for pre-surgery immunotherapy) - You have high TMB (tumor mutation burden), MSI-High, or dMMR status and are considering immunotherapy **You may NOT be eligible if...** - You are under 18 - You are unwilling to give consent or share health information - You do not have one of the qualifying cancer types Talk to your doctor to see if this trial is right for you.