RecruitingNCT05523245

Predicting the Efficacy of Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer Using an AI Platform Based on Multi-parametric MRI


Sponsor

Sixth Affiliated Hospital, Sun Yat-sen University

Enrollment

1,700 participants

Start Date

Jun 24, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

Establish a deep learning model based on multi-parameter magnetic resonance imaging to predict the efficacy of neoadjuvant therapy for locally advanced rectal cancer.This study intends to combine DCE with conventional MRI images for DL, establish a multi-parameter MRI model for predicting the efficacy of CRT, and compare it with the DL and non-artificial quantitative MRI diagnostic model constructed by conventional MRI to evaluate the role of DL in MRI predicting CRT. And this study also tries to build a DL platform to assess the efficacy of LARC neoadjuvant radiotherapy and chemotherapy, accurately assess patients' complete respose (pCR) after CRT, and provide an important basis for guiding clinical decision-making.


Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Clinical suspicion or colonoscopic pathology of rectal cancer
  • Age over 18 years
  • Informed consent and signed informed consent form

Exclusion Criteria8

  • Poor magnetic resonance image quality, such as severe artifacts
  • Previous treatment for rectal cancer
  • History or combination of other malignant tumours
  • Not Locally Advanced Rectal Cancer (LARC)
  • Not received neoadjuvant therapy or not completed neoadjuvant therapy
  • No surgery
  • Time interval between MRI and surgery was more than 2 weeks
  • Patients were lost to follow-up and voluntarily withdrew from the study due to adverse reactions or other reasons

Locations(4)

Sixth Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

The First Affiliated Hospital of Jinan University

Guangzhou, Guangdong, China

The Second Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

Fifth Affiliated Hospital, Sun Yat-sen University

Zhuhai, Guangdong, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05523245


Related Trials