RecruitingNCT05524090

PREOPANC-4 Implementation Program for Locally Advanced Pancreatic Cancer

Nationwide Implementation Program for Optimal Multidisciplinary Management and Resection of Locally Advanced Pancreatic Cancer (PREOPANC-4)

Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Enrollment

223 participants

Start Date

Jul 1, 2021

Study Type

OBSERVATIONAL

Conditions

Pancreatic Cancer Chemotherapy Effect Locally Advanced Pancreatic Adenocarcinoma Pancreatic Adenocarcinoma Non-resectable

Summary

A prospective, nationwide, implementation program of the international standard of excellence for locally advanced pancreatic cancer (LAPC) care in the Netherlands (2021\[7\]-2030\[6\]), including a multidisciplinary training program by the four leading international expert centers. The PREOPANC-4 project aims a safe and patient-centered implementation of the international standards of excellence for LAPC (surgery) in the Netherlands.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating whether patients with locally advanced pancreatic cancer (cancer that has grown into nearby structures but has not spread widely) who respond well to initial chemotherapy can benefit from adding a targeted radiation therapy (called SBRT — stereotactic body radiation therapy) before surgery. **You may be eligible if...** - You are 18 years or older - You have locally advanced pancreatic cancer confirmed by pathology - Your cancer has not progressed after at least 4 months of chemotherapy (FOLFIRINOX or gemcitabine-nab-paclitaxel) - You are being considered for surgery **You may NOT be eligible if...** - Your cancer had already spread to other organs (metastatic) before you started chemotherapy - Your tumor involves major blood vessels too extensively (per specific Dutch Pancreatic Cancer Group criteria) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERImplementation - International best-practice care

The PREOPANC-4 project aims to safely implement the international standard of excellence for LAPC management and surgery using a multidisciplinary best-practice training program, based on the experiences of four leading international expert centers (i.e. NYU Langone Health, University of Colorado, Heidelberg University, and MD Anderson Cancer Center). We hypothesize that the PREOPANC-4 implementation project will result in the improvement in multidisciplinary patient management and selection in line with current international best-practice.

Locations(1)

Amsterdam UMC, locatie AMC

Amsterdam, North Holland, Netherlands

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