RecruitingNCT05524090

PREOPANC-4 Implementation Program for Locally Advanced Pancreatic Cancer

Nationwide Implementation Program for Optimal Multidisciplinary Management and Resection of Locally Advanced Pancreatic Cancer (PREOPANC-4)

Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Enrollment

223 participants

Start Date

Jul 1, 2021

Study Type

OBSERVATIONAL

Conditions

Pancreatic Cancer Chemotherapy Effect Locally Advanced Pancreatic Adenocarcinoma Pancreatic Adenocarcinoma Non-resectable

Summary

A prospective, nationwide, implementation program of the international standard of excellence for locally advanced pancreatic cancer (LAPC) care in the Netherlands (2021\[7\]-2030\[6\]), including a multidisciplinary training program by the four leading international expert centers. The PREOPANC-4 project aims a safe and patient-centered implementation of the international standards of excellence for LAPC (surgery) in the Netherlands.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Age 18 years or older
Pathology-confirmed (LAPC)\*
CT-based non-progressive disease (RECIST criteria) after at least 4 months of systemic chemotherapy (\[m\]FOLFIRINOX / gemcitabine-nab-paclitaxel).

Exclusion Criteria2

Metastatic pancreatic cancer prior to induction chemotherapy.
According to the Dutch Pancreatic Cancer Group (DPCG) definition: \>90 degrees arterial tumor involvement (i.e. superior mesenteric artery, celiac axis, and/or hepatic artery) and/or portovenous involvement of either \>270 degrees or occlusion.

Interventions

OTHERImplementation - International best-practice care

The PREOPANC-4 project aims to safely implement the international standard of excellence for LAPC management and surgery using a multidisciplinary best-practice training program, based on the experiences of four leading international expert centers (i.e. NYU Langone Health, University of Colorado, Heidelberg University, and MD Anderson Cancer Center). We hypothesize that the PREOPANC-4 implementation project will result in the improvement in multidisciplinary patient management and selection in line with current international best-practice.