The Detection of Small Early Liver Cancer With Natural History Follow up

This study is looking for better ways to detect small, early-stage liver cancer (called hepatocellular carcinoma or HCC) and track how it naturally progresses over time. By following patients closely, researchers hope to improve early detection methods and treatment decisions. **You may be eligible if:** - You are 18 years or older - You have been diagnosed with small, early-stage liver cancer (1–3 tumors, each smaller than 3 cm) with preserved liver function - You have liver cirrhosis (scarring) from any cause, with or without liver cancer - Your diagnosis is recent (within the last 3 months) or you had a previous liver cancer that was fully treated more than 6 months ago and now have a new tumor in a different spot **You may NOT be eligible if:** - Your liver cancer is not confirmed or cannot be confirmed by biopsy (in cases without cirrhosis) - Your liver cancer has spread beyond the liver or is at an advanced stage - You are under 18 years old Talk to your doctor to see if this trial is right for you.