RecruitingNCT05539014

Tuberculosis Cohort Avicenne Hospital

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

250 participants

Start Date

Jan 18, 2023

Study Type

OBSERVATIONAL

Conditions

Tuberculosis, Pulmonary

Summary

Tuberculosis represents the second highest death rate from an infectious disease in the world, just after COVID-19. The most affected department of France is Seine-Saint-Denis. Since 2005, this department with difficult socio-economic conditions has the highest incidence rate in metropolitan France, higher than that of Paris. In 2012, the reporting rate was 10 times higher among people born abroad compared to those born in France, with the highest rates found among people born in sub-Saharan Africa and Asia. It is proposed to constitute for the first time in France a cohort of patients with tuberculosis disease to better understand the characteristics of patients with unfavorable treatment outcomes and ultimately, to propose solutions to obtain better control of tuberculosis. This study would recruit all patients with tuberculosis disease for at least 4 years associated with 1 year of follow-up for a total duration of the study of at least 5 years.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria3

Tuberculosis out- or in-patient newly treated in one of the inclusion centers for pulmonary or extra-pulmonary
Tu confirmed bacteriologically (direct examination, Gen-eXpert MTB/RIF and/or positive culture), suggestive histology (epithelioid gigantocellular granuloma with or without caseous necrosis), or strong clinical suspicion of tuberculosis, even if not yet biologically confirmed but with
A decision to introduce treatment.

Exclusion Criteria1

opposition to participate in the study, anti-tuberculosis treatment for more than 7 days at the inclusion visit and participation in another research protocol.

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