Ketorolac Intravenous Regional Analgesia in Lower Limb Surgeries
Ketorolac for Intravenous Regional Analgesia in Lower Limb Orthopedic Surgeries Under Spinal Anesthesia: A Randomized Control Study
Mansoura University
76 participants
Nov 1, 2022
INTERVENTIONAL
Conditions
Summary
Tourniquet, a compressing device, otherwise its use in intravenous regional anesthesia, is commonly used in particular orthopedic surgeries. From the previous documented effectiveness and safety of intravenous (IV) administration of ketorolac in the circulatory-isolated limb as a part of intravenous regional anesthesia; we hypothesized that in orthopedic surgeries done with tourniquet, intravenous (IV) administration of ketorolac after tourniquet inflation, will act as intravenous regional analgesia. So, it will prolong the postoperative analgesic duration as a primary outcome.
Eligibility
Inclusion Criteria2
- American Society of Anesthesiologists physical status I or II
- Elective unilateral lower limb orthopedic surgery with tourniquet under spinal anesthesia
Exclusion Criteria6
- Pregnant females
- Body mass index ≥ 35 kg/m2
- Allergy to ketorolac
- Had renal, asthmatic, vascular (Raynaud's syndrome) disease, hematological anemias
- Had any history of gastrointestinal tract inflammation, bleeding, ulceration, or perforation besides
- Edema in the operated limb grade ≥ 3
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
After confirmation of circulatory isolation of the operated limb by the inflated tourniquet, 30 mg ketorolac tromethamine diluted in normal saline in a total volume of 50 ml will be injected
After confirmation of circulatory isolation of the operated limb by the inflated tourniquet, 50 ml normal saline without drugs will be injected
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05543785