The Efficacy of Neoadjuvant Chemoradiotherapy in Comparison With Neoadjuvant Chemotherapy in Patients With Resectable Squamous Cell Esophageal Cancer

This trial is comparing two pre-surgery treatment approaches for people with a type of esophageal (food pipe) cancer — squamous cell carcinoma: one group receives chemotherapy combined with radiation before surgery, while the other receives chemotherapy alone. The goal is to see which approach leads to better outcomes. **You may be eligible if...** - You have been diagnosed with squamous cell carcinoma of the esophagus confirmed by biopsy - Your cancer is at a resectable stage (able to be surgically removed) - You are between 18 and 70 years old - You are in good physical condition (ECOG 0–1) - Your blood counts, liver, kidney, and heart function are within acceptable ranges **You may NOT be eligible if...** - Your cancer has spread to distant organs - You have had previous chemotherapy or radiation for esophageal cancer - You have severe heart, liver, or kidney problems - You are pregnant - Your cancer involves the cervical esophagus only Talk to your doctor to see if this trial is right for you.