RecruitingPhase 3NCT05551104

Safest Choice of Antihypertensive Regimen for Postpartum Hypertension

Safest Choice of Antihypertensive Regimen for Postpartum Hypertension: A Randomized Control Trial (SCARPH)

Sponsor

Loma Linda University

Enrollment

500 participants

Start Date

May 8, 2023

Study Type

INTERVENTIONAL

Conditions

Postpartum Complication High Blood Pressure Maternal Hypertension

Summary

The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.

Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria3

Female
Women who develop postpartum hypertension\* after delivery of the placenta or chronic hypertensive postpartum women who require medication for blood pressure control.
Postpartum hypertension requiring treatment are defined as systolic blood pressure greater than or equal to 140mmHg or diastolic blood pressure greater than or equal to 90mmHg on at least 2 occasions at least 4 hours apart, or systolic blood pressure greater than or equal to 160mmHg or diastolic blood pressure greater than 110mmHg sustained for more than 15 minutes.

Exclusion Criteria4

History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema
Contraindication to either Nifedipine or Labetalol
HR \<60 or \>110
Native language other than English or Spanish