RecruitingPhase 1Phase 2NCT05551507

IN10018 in Combination With Standard Chemotherapy in High-grade Serous Epithelial Ovarian Cancer

A Phase Ib/II, Open-label Clinical Study to Evaluate the Safety, Tolerability and Antitumor Activities of IN10018 in Combination With Standard Chemotherapy in Subjects With High-grade Serous Epithelial Ovarian Cancer


Sponsor

InxMed (Shanghai) Co., Ltd.

Enrollment

150 participants

Start Date

Jul 27, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This is a phase Ib/II, open label clinical study to evaluate the safety, tolerability and antitumor activities of IN10018 in combination with standard chemotherapy in subjects with high-grade serous ovarian cancer (including fallopian tube cancer and primary peritoneum cancer, collectively defined as ovarian cancer).


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a drug called IN10018 in combination with standard chemotherapy in women with high-grade serous ovarian, fallopian tube, or peritoneal cancer that has come back after being treated with platinum-based chemotherapy. **You may be eligible if...** - You are a woman 18 or older with confirmed high-grade serous ovarian, fallopian tube, or primary peritoneal cancer - Your cancer is platinum-resistant (it returned 1–6 months after completing at least 4 cycles of platinum-based therapy) - You have received no more than 5 prior lines of treatment - You have at least one measurable tumor on imaging - You are in good physical condition (ECOG 0–1) **You may NOT be eligible if...** - Your cancer is a different subtype (not high-grade serous) - You have active brain metastases - You have had prior FAK inhibitor therapy - You are pregnant or breastfeeding - You have significant organ dysfunction Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIN10018 in combination with PLD

IN10018 in combination with PLD to treat subjects with platinum-resistant recurrent ovarian cancer


Locations(7)

Anyang Cancer Hospital

Anyang, China

Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College

Beijing, China

Hunan Cancer Hospital

Changsha, China

Fujian Cancer Hospital

Fuzhou, China

Affiliated Obstetrics and Gynecology Hospital of Zhejiang University

Hangzhou, China

Tianjin Cancer Hospital

Tianjin, China

Henan Cancer Hospital

Zhengzhou, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT05551507


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