RecruitingNot ApplicableNCT05556902

Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

Sponsor

University of Alabama at Birmingham

Enrollment

80 participants

Start Date

Aug 2, 2022

Study Type

INTERVENTIONAL

Conditions

Hypertension Blood Pressure Low Back Pain

Summary

The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).

Eligibility

Min Age: 18 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how a spinal cord stimulator (a device implanted near the spine to treat chronic pain) actually works to reduce pain in the brain and body. Researchers will measure brain activity and blood markers to understand the mechanisms behind this treatment. **You may be eligible if:** - You are between 18 and 89 years old - You have had chronic pain for more than 3 months - You are willing to visit a research lab and provide a blood sample **You may NOT be eligible if:** - You have a neurological disease such as dementia or Parkinson's disease - You have had a stroke - You currently have cancer - You are unwilling or unable to follow the study protocol Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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