Low Back Pain Clinical Trials

223 recruitingLast updated: June 18, 2026

There are 223 actively recruiting low back pain clinical trials across 34 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1, Phase 1. Top locations include Lahore, Punjab Province, Pakistan, Salt Lake City, Utah, United States, Leuven, Belgium. Updated daily from ClinicalTrials.gov.


Low Back Pain Trials at a Glance

223 actively recruiting trials for low back pain are listed on ClinicalTrialsFinder across 6 cities in 34 countries. The largest study group is Not Applicable with 160 trials, with the heaviest enrollment activity in Lahore, Salt Lake City, and Leuven. Lead sponsors running low back pain studies include Riphah International University, Foundation University Islamabad, and Cairo University.

Browse low back pain trials by phase

Treatments under study

About Low Back Pain Clinical Trials

Looking for clinical trials for Low Back Pain? There are currently 152 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Low Back Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Low Back Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 223 trials

Recruiting
Not Applicable

A Prospective Study to Evaluate the Efficacy of Iovera Lumbar Medial Branch Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain

Low Back Pain, Chronic
Montefiore Medical Center110 enrolled1 locationNCT07214844
Recruiting
Not Applicable

Imaging Metabolic and Perfusion Changes in Acupuncture Therapy for Myofascial Pain Syndrome

Chronic Low Back Pain (CLBP)Myofascial Pain Syndrome (MPS)
University of California, Davis64 enrolled1 locationNCT07494162
Recruiting

Isokinetic Profile of Ankle Joint Muscles in Chronic Non Specific Low Back Pain Patients

Chronic non-specific low back pain
Cairo University50 enrolled1 locationNCT07636967
Recruiting
Not Applicable

Assessment of the Evolution of Lumbar Spine Movement Fluidity Using Xsens Inertial Sensors in Subjects With Chronic Low Back Pain Before and After Rehabilitation

Low Back Pain
University Hospital, Montpellier25 enrolled1 locationNCT07327554
Recruiting

Wearable Spine Assessment in Adults With and Without Low Back or Neck Pain

Low Back PainNeck Pain
Ashkan Vaziri20 enrolled1 locationNCT07643207
Recruiting
Not Applicable

Comparison of High-Intensity Interval Training With Moderate-Intensity Continuous Training in Chronic Non-Specific Low Back Pain Patients

Chronic non-specific low back pain
Dow University of Health Sciences80 enrolled1 locationNCT07645859
Recruiting
Not Applicable

Evaluation of the Japet.W+ Medical Device for Low Back Pain Management

Low Back Pain
Japet Medical Devices102 enrolled1 locationNCT07195422
Recruiting
Not Applicable

Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

Chronic leg painLeg painChronic Low-back Pain+3 more
Boston Scientific Corporation70 enrolled7 locationsNCT07190807
Recruiting
Not Applicable

Contextual Effects on Inflammatory Biomarkers and Pain Relief After Spinal Joint Manipulation

Low Back Pain
John Paul II University in Biała Podlaska73 enrolled2 locationsNCT07507604
Recruiting
Not Applicable

Low Blood Flow Restriction Training on Low Back Pain

Low Back Pain
Riphah International University44 enrolled1 locationNCT07576101
Recruiting
Early Phase 1

Brain Mechanisms Supporting Cannabis-induced Pain Relief

Chronic Low Back Pain (CLBP)SciaticaLumbar Radiculopathy+4 more
University of California, San Diego100 enrolled1 locationNCT04982965
Recruiting

Effect of Lumbar Surgery on Complexity During a Walking Task in Chronic Low Back Pain

Low Back Pain
Centre Hospitalier Universitaire de Nīmes32 enrolled2 locationsNCT05231265
Recruiting

Examination of Nociscan Impact on Discogenic Low Back Pain Surgical Outcomes

Discogenic Low Back Pain
Aclarion300 enrolled8 locationsNCT06661850
Recruiting
Not Applicable

Chronic Low Back Pain and Osteopathic Manipulation Treatment

Chronic Low Back Pain (CLBP)Low Back Pain
Edward Hines Jr. VA Hospital48 enrolled1 locationNCT07161661
Recruiting
Not Applicable

Comprehensive Biopsychosocial Approach for Acute Low Back Pain Management in the Emergency Department: a Stepped-wedge Cluster-randomized Clinical Trial

Non-traumatic Low Back Pain
Assistance Publique - Hôpitaux de Paris782 enrolled1 locationNCT07375914
Recruiting
Phase 3

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Chronic Low Back Pain (CLBP)ObesityOverweight
Eli Lilly and Company586 enrolled40 locationsNCT07035093
Recruiting
Not Applicable

Comparative Effects Of Post Isometric Relaxation Versus Active Isolated Stretch In Patients With Piriformis Syndrome

Low Back PainPiriformis SyndromeHip Joint
Foundation University Islamabad40 enrolled1 locationNCT07526012
Recruiting
Not Applicable

Sensorimotor Training With a Mobilized Balance Platform in Patients With Chronic Low Back Pain

Low Back Pain
Gaziler Physical Medicine and Rehabilitation Education and Research Hospital44 enrolled1 locationNCT07603609
Recruiting

Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain: A Cross Sectional Study

MigraineLow Back PainNeck Pain
Bozok University179 enrolled1 locationNCT07567300
Recruiting
Phase 2

Dronabinol as an Adjunct for Reducing Pain

Chronic PainLow Back PainBack Injuries
Christopher D. Verrico75 enrolled1 locationNCT06454669