RecruitingNCT05558059

Imaging Retinal Vasculature in Infant Eyes

Elucidating Perifoveal Vasculature Development in Infants

Sponsor

Duke University

Enrollment

16 participants

Start Date

Oct 3, 2024

Study Type

OBSERVATIONAL

Conditions

Retinopathy of Prematurity

Summary

Retinopathy of prematurity is a leading cause of childhood blindness worldwide. The fovea, a critical location in the retina determining visual acuity and visual function, and the blood vessels around it, are abnormally developed in infants with retinopathy of prematurity. However, how these blood vessels form during development of the human fovea remains unclear. This research will advance our understanding of the fundamental knowledge of how the blood vessels around the fovea form in infants, and how they change in diseased states such as preterm birth or retinopathy of prematurity.

Eligibility

Max Age: 2 Months

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Handheld Optical Coherence Tomography with OCT Angiography for people with retinopathy of prematurity. The study is currently recruiting participants at 2 locations. People eligible for this study include up to age 2 Months.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEHandheld Optical Coherence Tomography with OCT Angiography

OCT systems are in vivo optical imaging technology that allows non-contact imaging of early-stage ocular pathology. They create real-time, non-invasive images of ocular microstructure and have become standard-of-care instruments in ophthalmic imaging in clinics and operating rooms. In contrast to the visible light used in clinical eye examinations, because infrared light is not visible, the participant is not disturbed by the light. OCT imaging allows the capture of hundreds of B-scan (cross-sectional) images in seconds. These B-scans are analyzed for depth-resolved information and can also be stacked to create a volume and the stack may be summed up to create a retinal image. OCT angiography (OCTA) is an extension of the OCT systems, by taking images at the same location over time to extract retinal vascular flow information. It has been utilized to assess the ocular blood flow in many adult and pediatric patients.