RecruitingNCT05558111

The Supraspinal Control of Lower Urinary Tract Function in Patients with Orthotopic Sigmoid Neobladder.

Neuroimaging Study of Supraspinal Control of Lower Urinary Tract Function in Patients with Orthotopic Sigmoid Neobladder.


Sponsor

Zhujiang Hospital

Enrollment

40 participants

Start Date

Jun 1, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

Orthotopic sigmoid neobladder surgery is one of the ideal urinary diversion methods after radical cystectomy.In recent years, functional imaging studies have revealed brain regions related to urinary system function, but brain activity of lower urinary tract function in neobladder patients is still unclear.The aim of this study is to explore the brain activity of urination intention and self-controlled urination behavior in patients with orthotopic sigmoid neobladder by task-state functional magnetic resonance imaging (fMRI).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using functional MRI (fMRI) brain scans to understand how the brain controls bladder function in patients who have had their bladder replaced with a surgically constructed pouch made from part of the intestine (called a neobladder). **You may be eligible if:** - You are right-handed - It has been at least 3 months since your neobladder surgery - You are willing to have an MRI scan and sign a consent form **You may NOT be eligible if:** - You have had prior bladder radiation - You have a history of prostate cancer - You have neurological conditions (such as Parkinson's, Alzheimer's, epilepsy, or a prior stroke) - You have mental health disorders - You have claustrophobia or metal implants that prevent MRI - You have spinal cord injury or diabetic nerve damage affecting the bladder - You have urethral stricture (narrowing of the urethra) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

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NCT05558111