RecruitingPhase 1NCT05565118

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma (WHO Grade III and IV) as a Predictor of Progression

Sponsor

Case Comprehensive Cancer Center

Enrollment

10 participants

Start Date

Apr 9, 2024

Study Type

INTERVENTIONAL

Conditions

Glioblastoma High Grade Glioma

Summary

The purpose of this study is to test the safety and feasibility of recording brain activity within and around high-grade glioma tumors at the time of surgery. A small biopsy will be taken at the sites of the recordings.

Eligibility

Min Age: 18 Years

Inclusion Criteria12

Participants who have the appearance of high-grade glioma (HGG, WHO Grade 3 and 4, including GBM) on MR imaging are allowed to consent and will undergo the procedure if the frozen is consistent with HGG
OR
Participants with a history of histologically-confirmed diagnosis of high- grade glioma that are undergoing resection of a recurrent/progressive tumor that is likely recurrent/progressive high- grade glioma as identified on preoperative MR imaging
Age ≥ 18 years old
Volumetric MRI within 1 month prior to surgery
Karnofsky performance status of 60 or higher
The participant (or legally acceptable representative if applicable) provides written informed consent for the trial.
Participants must be considered appropriate neurosurgical candidates with the following screening/baseline laboratory values within 1 month prior to surgery:
Absolute neutrophil count ≥ 1500/µL
Platelets ≥ 100 000/µL
International normalized ratio (INR) OR prothrombin time (PT) Activated partial thromboplastin time (aPTT) ≤1.5 × Upper limit of normal (ULN) unless participant is receiving anticoagulant therapy as long as PT or aPTT is within therapeutic range of intended use of anticoagulants
Urine or Serum Pregnancy Test = Negative (Not applicable to participants with bilateral oophorectomy and/or hysterectomy or to those participants who are postmenopausal).

Exclusion Criteria5

Severe co-morbidity that would confer excess risk of surgery as determined by the treating physician.
Any other major medical illnesses or psychiatric impairments that in the investigator's opinion will prevent administration or completion of protocol therapy.
Is pregnant
Coagulopathy or platelet dysfunction that increases the risk of intra and postoperative hemorrhage
Tumor location requiring DE placement/biopsy in eloquent or critical region of the brain (e.g. primary motor and sensory cortices, speech and vision centers, thalamus, basal ganglia, cerebellum, brain stem) as deemed by the neurosurgeon designing the surgical plan

Interventions

PROCEDUREStandard Surgical Treatment

During this surgery, participants will also undergo a tissue biopsy at recording sites for correlation to neural recording data.

PROCEDUREIntraoperative Electrocorticography

Each participant will undergo intraoperative electrocorticography (ECOG) through subdural grid (SDG) and depth electrode (DE) via FDA-cleared, standardized, brain recording technology.