Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

This surgical study is examining patterns of electrical activity in high-grade brain tumors (gliomas, including glioblastoma) during surgery. By recording how tumor cells communicate electrically, researchers hope to find markers that predict how quickly the tumor will return or progress after treatment. **You may be eligible if...** - You are 18 or older - Brain imaging suggests a high-grade glioma (WHO Grade 3 or 4, including glioblastoma), and you are scheduled for surgery OR - You have a previously confirmed high-grade glioma and are having surgery for a recurrence - You had a detailed brain MRI within 1 month before surgery - Your overall health is reasonably good (Karnofsky performance status ≥60) - Your blood counts and clotting tests meet minimum requirements **You may NOT be eligible if...** - You have serious medical conditions that make surgery too risky - You have psychiatric conditions that would prevent you from participating - You are pregnant - You have clotting problems - The tumor is in a critical or sensitive part of the brain where the recording device cannot safely be placed Talk to your doctor to see if this trial is right for you.