Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

This study is testing transcranial near-infrared radiation (tNIR) — a non-invasive light-based therapy applied to the head — to see if it improves blood flow in the brain and reduces depression symptoms. Researchers believe this approach may help regulate mood in people with major depressive disorder. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with major depressive disorder (MDD) and currently have significant depression symptoms - Your score on a standard depression scale is 23 or higher - You are willing to use contraception if you are a woman of childbearing age **You may NOT be eligible if...** - You have an active serious medical or psychiatric condition that would interfere with the study - You have a condition that makes it unsafe to receive the light-based treatment - Your depression is not the primary condition being treated Talk to your doctor to see if this trial is right for you.