RecruitingNot ApplicableNCT05574647

Imperial Prostate 7 - Prostate Assessment Using Comparative Interventions - Fast Mri and Image-fusion for Cancer

Evaluating the Role of Biparametric MRI and Image-fusion Targeted Biopsies for Detection of Prostate Cancer


Sponsor

Imperial College London

Enrollment

3,600 participants

Start Date

Nov 2, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

To evaluate the role of biparametric MRI and image-fusion targeted biopsies for the detection of prostate cancer. To determine whether biparametric MRI (bpMRI) could be recommended as an alternative to multiparametric MRI (mpMRI) for the detection of clinically significant prostate cancers in patients at risk. To determine whether image-fusion targeted biopsy is better than visual-registration (cognitive) targeted biopsy at detecting clinically significant prostate cancers in patients requiring prostate biopsy due to a suspicious MRI.


Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial compares a faster MRI approach to standard MRI for diagnosing prostate cancer, and also compares different types of biopsies to find the most accurate and least invasive method. You may be eligible if... - You are 18 years or older with a prostate - You were referred for a prostate MRI due to an abnormal rectal exam or elevated PSA level - Your PSA is above the age-adjusted threshold (e.g., 3.0+ ng/mL for ages 50-69) You may NOT be eligible if... - Your PSA is above 50 ng/mL - You have had a prostate MRI or biopsy in the last two years - You have already been diagnosed with prostate cancer - You have a reason you cannot have an MRI or gadolinium contrast - You have had hip replacements in both hips Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTbpMRI

biparametric MRI takes 30-40 minutes and requires a contrast injection called gadolinium (like a dye). This is also called long MRI and is most commonly used in the NHS.

DIAGNOSTIC_TESTImage-Fusion targeted and systematic Biopsy

During image fusion targeted biopsy, the biopsy operator uses the MRI scans that were taken beforehand but laid on top of the live ultrasound images during the biopsy. This uses software and takes a few minutes longer to perform. Once the MRI images and ultrasound images are 'fused', the actual biopsies are taken as normal.


Locations(15)

Southend University Hospital

Southend-on-Sea, Essex, United Kingdom

University Hospital Southampton

Southampton, Hampshire, United Kingdom

Medway Maritime Hospital

Gillingham, Kent, United Kingdom

Basingstoke Hospital

Basingstoke, United Kingdom

Southmead Hospital

Bristol, United Kingdom

Addenbrooke Hospital, Cambridge

Cambridge, United Kingdom

Cumberland Infirmary

Carlisle, United Kingdom

St Peters Hospital

Chertsey, United Kingdom

Darent valley Hospital

Dartford, United Kingdom

Northwick Park Hospital

Harrow, United Kingdom

St James's Hospital, Leeds

Leeds, United Kingdom

Charing Cross Hospial

London, United Kingdom

Manchester Royal Infirmary

Manchester, United Kingdom

Northampton General Hospital

Northampton, United Kingdom

Hillingdon Hospital

Uxbridge, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT05574647


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