RecruitingNCT05575440

Evaluation of 18F-TFB PET/CT Scan in Patients With Differentiated Thyroid Cancer

Evaluation of F-18 Tetrafluoroborate (18F-TFB) PET/CT in Patients With Differentiated Thyroid Cancer

Sponsor

Mayo Clinic

Enrollment

24 participants

Start Date

Apr 22, 2022

Study Type

OBSERVATIONAL

Conditions

Thyroid Gland Follicular Carcinoma Thyroid Gland Papillary Carcinoma Differentiated Thyroid Gland Carcinoma

Summary

This phase II study evaluates F-18 tetrafluoroborate (18F-TFB) PET/CT scan in patients with differentiated thyroid cancer. Diagnostic imaging is necessary for planning treatment, monitoring therapy response, and identifying sites of recurrent or metastatic disease in differentiated thyroid cancer. 18F-TFB PET/CT may accurately detect recurrent and metastatic thyroid cancer lesions, with the potential to provide information for patient management that is better than the current standard of care imaging practices.

Eligibility

Min Age: 18 Years

Inclusion Criteria8

Subject has biopsy-proven papillary or follicular thyroid cancer
Subject is clinically indicated for 123I-SPECT/CT total body iodine (TBI) scan
Subject agrees to undergo 18F-TFB PET/CT scan following TBI scan
Karnofsky performance status of \>= 50 (or Eastern Cooperative Oncology Group \[ECOG\]/World Health Organization \[WHO\] equivalent)
Subject is able to be scanned - able to lie still on SPECT/CT and PET/CT scanner table for up to 65 minutes (min)
Age 18 or older
Ability to understand a written informed consent document, and the willingness to sign it
Subject is not pregnant

Exclusion Criteria9

Contrast-enhanced CT within 4 last weeks
Amiodarone within last 4 months
Ingested iodine, kelp tablets, Lugols iodine, or potassium iodide (SSKI) within 2 weeks
Unable to lie flat, still or tolerate a PET scan
Applied betadine, iodoform, or quick tanning products to skin within last two weeks
If using medication withdrawal for stimulation, then exclude if thyroid stimulating hormone (TSH) level \< 25
Taken anti-thyroid medication within 1 week
Subject is breastfeeding
Positive pregnancy test

Interventions

PROCEDUREComputed Tomography

Undergo a PET/CT scan

RADIATIONFluorine F 18 Tetrafluoroborate

Given IV

PROCEDUREPositron Emission Tomography

Undergo a PET/CT scan

OTHERSurvey Administration

Ancillary studies

Locations(1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

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NCT05575440

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