RecruitingNot ApplicableNCT05577845
5-HT3 Receptor Antagonist (Ramosetron) vs Loperamide for the Treatment of Low Anterior Resection Syndrome(RALARS)
Safety & Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) Versus Loperamide for the Treatment of Low Anterior Resection Syndrome (RALLARS): Multicenter Randomized Controlled Trial
Sponsor
Seoul National University Hospital
Enrollment
212 participants
Start Date
Mar 27, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
Safety \& Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) versus Loperamide for the Treatment of Low Anterior Resection Syndrome (RALLARS): Multicenter Randomized Controlled Trial
Eligibility
Min Age: 19 Years
Inclusion Criteria5
- mid and low rectal cancer (AV<15cm)
- stage II, III, preop long-course CCRT, then ileostomy repair
- about 1~12 months after operation (no stomy)
- about 1~6 months after ileostomy repair
- major LARS
Exclusion Criteria4
- recurred rectal cancer
- stage IV
- IBD
- uncontrolled preoperative fecal incontinence or constipation
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Interventions
DRUGRamosetron
Ramosetron, 4 weeks
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05577845
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