Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension

This study is investigating how a hormone system called the mineralocorticoid receptor affects heart and blood vessel function in people with high blood pressure and an enlarged heart muscle (left ventricular hypertrophy). Researchers aim to understand the underlying biology to develop better treatments. **You may be eligible if...** - You have high blood pressure (whether or not you are on medication) - An echocardiogram (heart ultrasound) shows your heart muscle is thickened (left ventricular hypertrophy) - You may also have treated hypothyroidism, pre-diabetes, or diabetes managed without medications (except metformin) **You may NOT be eligible if...** - You have taken certain blood pressure medications (spironolactone, eplerenone, finerenone, or amiloride) in the past year - You have low blood pressure when standing (orthostatic hypotension) - You have significantly reduced heart pumping function (ejection fraction below 40%) - You have severe heart failure (Class III–IV) Talk to your doctor to see if this trial is right for you.