RecruitingPhase 2NCT05594563

TArgeting Type 1 Diabetes Using POLyamines (TADPOL)

TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes

Sponsor

Emily K. Sims

Enrollment

70 participants

Start Date

Mar 14, 2023

Study Type

INTERVENTIONAL

Conditions

Type 1 Diabetes

Summary

The goal of this clinical trial is to test a drug known as DFMO in people with Type 1 Diabetes (T1D). The main question\[s\] it aims to answer are: * Does it reduce stress on the cells that make insulin? * Does it preserve what is left of the body's insulin production? Participants will take either DFMO or a placebo (looks like DFMO but has no active ingredients) two times a day for about 6 months. Participants will have 6 in person visits and 1 phone visit over a period of 12 months. Visits will include blood draws urine collection and other tests.

Eligibility

Min Age: 4 YearsMax Age: 40 Years

Inclusion Criteria6

Males and females 4- ≥40 years of age with a clinical diagnosis of T1D
T1D clinical diagnosis with insulin start date no more than 100 days prior to the time of randomization
Random non-fasting C-peptide level of \>0.2 pmol/mL (equivalent to \>0.6ng/ml) at screening.
Positive for any one of the following diabetes-related autoantibodies (IAA, GAA, IA-2, or ZnT8)
Treatment naïve of any immunomodulatory agent
Normal hearing at screening, defined as acceptable results of pure-tone audiometry (\<20 decibel \[dB\] baseline thresholds forall frequencies tested

Exclusion Criteria17

Presence of severe, active disease that interferes with dietary intake or requires the use of chronic medication, with the exception of well-controlled hypothyroidism and mild asthma not requiring oral steroids. Presence of any psychiatric disorder that will affect ability to participate in study.
Diabetes other than T1D
Chronic illness known to affect glucose metabolism (e.g. Cushing syndrome, polycystic ovarian disorder, cystic fibrosis) or taking medications that affect glucose metabolism (e.g. steroids, metformin)
Inability to swallow pills
Psychiatric impairment or current use of anti-psychotic medication
Any condition that, in the investigator's opinion, may compromise study participation or may confound the interpretation of the study results.
Neutropenia (\< 1,500 neutrophils/μL)
Leukopenia (\< 3,000 leukocytes /μL)
Lymphopenia ( \< 800 lymphocytes/μL)
Thrombocytopenia (\<100,000 platelets/μL)
Clinically significant anemia or Hemoglobin as defined below:
In Adults: Hgb \<12.0g/dL in females and \<13.0g/dL in males In Children: 12- \<18: \<11.4 g/dL in females and \<12.4 g/dL in males In Children: 4- \<12: Hgb \<11.2 g/dL
Impaired renal function (assessed by history and BUN/Creatinine, DFMO is renally excreted)
Allergy to milk or soy (components of Boost® drink used for mixed meal tolerance testing)
Female participants of child-bearing age with reproductive potential, must not be pregnant and agree to use 2 effective forms of birth control or be abstinent during the study period (see below). Male participants (including men who have had vasectomies) whose partners are pregnant or may be pregnant should use condoms while on study drug, until 2 weeks after discontinuation of drug, while the partner is pregnant.
Active seizure disorder, defined as requiring chronic medication at the time of study or having had a seizure within the past 12 months at the time of screening
Enrollment into another intervention trial.