RecruitingNot ApplicableNCT05595577

Improving Exercise Capacity With a Tailored Physical Activity Intervention

Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment


Sponsor

Wake Forest University Health Sciences

Enrollment

110 participants

Start Date

Mar 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this research is to test whether participating in either a physical activity intervention or a series of educational classes will help to preserve exercise capability, heart function, brain-based activities (like memory), and quality of life. Participants will be randomized to 1 of 2 pathways: * First pathway consists of organized health workshops. These workshops are intended to provide information on topics such as proper nutrition, management of stress, sleep practices, and emphasis on a healthy lifestyle that may help the participants through cancer treatment. This pathway will also test whether stretching may help participants through cancer treatment. * Second pathway participants will take part in some unsupervised and some potentially supervised moderate activity sessions each week throughout participants' cancer treatment to take place either remotely or in person, depending on availability of facilities at the time visits are scheduled.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a personalized exercise program can help protect heart health and improve fitness in people with lymphoma or breast cancer who are receiving treatments known to cause heart damage, such as certain chemotherapy drugs or radiation. **You may be eligible if...** - You are 18–85 years old - You have been diagnosed with Hodgkin or non-Hodgkin lymphoma (any stage) or stage I–III breast cancer - You are scheduled to receive a treatment that can affect heart health (such as anthracyclines, trastuzumab, rituximab, immune checkpoint inhibitors, or radiation) - You can walk at least 2 city blocks and understand English **You may NOT be eligible if...** - You have severely uncontrolled high blood pressure (above 190/100) - You have recent serious alcohol or drug use, lupus, inflammatory bowel disease, or another condition that may interfere with safe exercise participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERExercise with Trainerize application

1-2 sessions per week consisting of slow 15 minute aerobic warm, 20 minutes of strength training, 15 minutes progressive intensity aerobic exercise and 10 minute cool down (stretching/toning) with elastic bands.

DIAGNOSTIC_TESTCardiopulmonary exercise testing

Maximal peak VO2 (to monitor the body's oxygen consumption) and 6-minute exercise walking test.

DIAGNOSTIC_TESTMRI scan

Images of the heart will be taken.

BEHAVIORALQuality of Life Questionnaires

Participants will be asked to complete several questionnaires that will measure fatigue, general health, social determinants of health, cognitive function (tasks that assess memory, ability to count, etc.) and physical activity. The questionnaires will take 15-40 minutes to complete.

BEHAVIORALCognitive and Brain Function Questionnaires

Participants will be asked to complete several questionnaires that will measure fatigue, general health, social determinants of health, cognitive function (tasks that assess memory, ability to count, etc.) and physical activity. The questionnaires will take 15-40 minutes to complete.

OTHERBlood draws

Approximately 2 teaspoons of blood withdrawn from either a vein in your arm or a currently placed central line port-a-cath. A portion of blood from each visit will be used to collect information about blood cell count.


Locations(2)

Wake Forest Baptist Comprehensive Cancer Center

Winston-Salem, North Carolina, United States

Virginia Commonwealth University

Richmond, Virginia, United States

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NCT05595577


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