RecruitingPhase 3NCT05595642

A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Astegolimab in Patients With Chronic Obstructive Pulmonary Disease


Sponsor

Hoffmann-La Roche

Enrollment

1,290 participants

Start Date

Dec 29, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This study will evaluate the efficacy and safety of astegolimab compared with placebo in participants with chronic obstructive pulmonary disease (COPD) who are former or current smokers and have a history of frequent exacerbations.


Eligibility

Min Age: 40 YearsMax Age: 80 Years

Inclusion Criteria8

  • Documented COPD diagnosis for ≥ 12 months
  • History of frequent exacerbations, defined as having had 2 or more moderate or severe COPD exacerbations within 12 months prior to screening
  • Post-bronchodilator FEV1 ≥ 20% and \< 80% of predicted at screening
  • Post-bronchodilator FEV1/FVC \< 0.70 at screening
  • Modified Medical Research Council (dyspnea scale) (mMRC) score ≥ 2
  • Current tobacco smoker or former smoker with a history of smoking ≥ 10 pack-years
  • On optimized COPD maintenance therapy as defined below for ≥ 12 months prior to screening, and stable on current therapy for at least 4 weeks prior to screening: Inhaled corticosteroid (ICS) plus long-acting beta-agonist (LABA), Long-acting muscarinic antagonist (LAMA) plus LABA, ICS plus LAMA plus LABA
  • Chest X-ray or computed tomography (CT) scan within 6 months prior to screening or chest X-ray during the screening period that confirms the absence of clinically significant lung disease besides COPD

Exclusion Criteria12

  • Current documented diagnosis of asthma
  • History of clinically significant pulmonary disease other than COPD
  • Diagnosis of 1-antitrypsin deficiency
  • History of long-term treatment with oxygen at \> 4.0 liters/minute
  • Lung volume reduction surgery or procedure within 12 months prior to screening
  • Individuals participating in, or scheduled for, an intensive COPD rehabilitation program (participants who are in the maintenance phase of a rehabilitation program are eligible)
  • History of lung transplant
  • Any infection that resulted in hospital admission for ≥ 24 hours and/or treatment with oral, IV, or IM antibiotics within 4 weeks prior to or during screening
  • Upper or lower respiratory tract infection within 4 weeks prior to or during screening
  • Treatment with oral, IV, or IM corticosteroids within 4 weeks prior to initiation of study drug
  • Initiation of or change in non-biologic immunomodulatory or immunosuppressive therapy within 3 months prior to screening
  • Unstable cardiac disease, myocardial infarction, or New York Heart Association Class III or IV heart failure within 12 months prior to screening

Interventions

DRUGAstegolimab

Participants will receive SC astegolimab Q2W or Q4W

DRUGPlacebo

Participants will receive SC placebo Q2W


Locations(462)

Pinnacle Research Group

Anniston, Alabama, United States

AllerVie Clinical Research

Birmingham, Alabama, United States

Synexus Clinical Research US, Inc. - Birmingham

Birmingham, Alabama, United States

University of Alabama at Birmingham

Birmingham, Alabama, United States

SEC Clinical Research LLC - Dothan 2 - ClinEdge - PPDS

Dothan, Alabama, United States

Pulmonary Associates PA

Glendale, Arizona, United States

Synexus Clinical Research US, Inc. - Phoenix West

Glendale, Arizona, United States

AES - DRS - Synexus Clinical Research US, Inc. - Tucson

Tucson, Arizona, United States

Lynn Institute of The Ozarks - ERN - PPDS

Little Rock, Arkansas, United States

Kern Research

Bakersfield, California, United States

VA Palo Alto Health Care System

Palo Alto, California, United States

AES - DRS - Synexus Clinical Research US, Inc. - Vista

Vista, California, United States

Allergy & Asthma Medical Group of the Bay Area

Walnut Creek, California, United States

Cornerstone Research Institute

Altamonte Springs, Florida, United States

Invictus Clinical Research Group, LLC

Coconut Creek, Florida, United States

Finlay Medical Research Corporation

Greenacres City, Florida, United States

San Marcus Research Clinic Inc.

Miami, Florida, United States

Oceane7 Medical & Research Center, Inc.

Miami, Florida, United States

Avantis Clinical Research, LLC

Miami, Florida, United States

Research Institute of South Florida Inc

Miami, Florida, United States

Diverse Clinical Research, LLC

Miami, Florida, United States

Central Florida Pulmonary Group, PA

Orlando, Florida, United States

Revival Clinical Research

Orlando, Florida, United States

Florida Institute for Clinical Research, LLC

Orlando, Florida, United States

Ormond Beach Clinical Research

Ormond Beach, Florida, United States

Tampa Bay Health Care

Tampa, Florida, United States

AES - DRS - Synexus Clinical Research US, Inc. - The Villages

The Villages, Florida, United States

AES - DRS - Synexus Clinical Research US, Inc. - Atlanta

Atlanta, Georgia, United States

Allergy Center at Brookstone Research - Centricity Research - HyperCore - PPD

Columbus, Georgia, United States

Pivotal Research Solutions

Stonecrest, Georgia, United States

ASHA Clinical Research - ClinEdge - PPDS

Hammond, Indiana, United States

The Research Group of Lexington, LLC

Lexington, Kentucky, United States

Best Clinical Trials

New Orleans, Louisiana, United States

Paul A. Shapero, MD, PA

Bangor, Maine, United States

Pulmonary Research Institute of Southeast Michigan

Farmington Hills, Michigan, United States

Flushing Road Internal Medicine and Pediatrics - F

Flint, Michigan, United States

Revive Research Institute

Lathrup Village, Michigan, United States

Oakland Medical Research Center

Troy, Michigan, United States

Washington University School of Medicine in St. Louis

St Louis, Missouri, United States

Nebraska Medical Research Institute, Inc. - CRN

Bellevue, Nebraska, United States

Machuca Family Medicine

Las Vegas, Nevada, United States

Renown Regional Medical Center Hospital

Reno, Nevada, United States

Hassman Research Institute - HRI - Berlin - CenExel - PPDS

Marlton, New Jersey, United States

AES - DRS - Synexus Clinical Research US, Inc. - New York

New York, New York, United States

WellNow Urgent Care and Clinical Research - Niskayuna

Schenectady, New York, United States

Research Carolina Elite

Denver, North Carolina, United States

Care Access Research - Fayetteville - PPDS

Fayetteville, North Carolina, United States

Clinical Research of Gastonia

Gastonia, North Carolina, United States

Pulmonix LLC

Greensboro, North Carolina, United States

Advanced Respiratory and Sleep Medicine, PLLC

Huntersville, North Carolina, United States

Southeastern Research Center

Winston-Salem, North Carolina, United States

Wellnow Urgent Care and Research ? Springdale

Cincinnati, Ohio, United States

WellNow Urgent Care & Research - Huber Heights

Huber Heights, Ohio, United States

OK Clinical Research

Edmond, Oklahoma, United States

Vital Prospects Clinical Research Institute PC - CRN

Tulsa, Oklahoma, United States

The Oregon Clinic

Portland, Oregon, United States

Clinical Research Associates Of Central Pa , Llc

Altoona, Pennsylvania, United States

Allergy & Clinical Immun Assoc

Pittsburgh, Pennsylvania, United States

Medtrial, LLC

Columbia, South Carolina, United States

Velocity Clinical Research - Gaffney - PPDS

Gaffney, South Carolina, United States

Care Access Research - Mauldin - PPDS

Mauldin, South Carolina, United States

ClinSearch, LLC

Chattanooga, Tennessee, United States

Clinical Trials Center of Middle Tennessee

Franklin, Tennessee, United States

Tennessee Comprehensive Lung & Sleep Center

Hendersonville, Tennessee, United States

FutureSearch Trials of Neurology

Austin, Texas, United States

TTS Research

Boerne, Texas, United States

Corsicana Medical Research

Corsicana, Texas, United States

Baylor University Medical Center

Dallas, Texas, United States

Epic Medical Research LLC - DeSoto

DeSoto, Texas, United States

Greater Heights Memorial Pulmonary and Sleep

Houston, Texas, United States

Trio Clinical Trials

Houston, Texas, United States

Baylor College of Medicine Medical Center

Houston, Texas, United States

Uni of Texas Health Science Center At Houston

Houston, Texas, United States

Clinical Trial Network

Houston, Texas, United States

Biopharma Informatic - Park Row - PPDS

Houston, Texas, United States

Advances In Health Inc

Houston, Texas, United States

R & H Clinical Research

Katy, Texas, United States

R & H Clinical Research

Katy, Texas, United States

University of Vermont Medical Center

Burlington, Vermont, United States

Western Washington Medical Group

Everett, Washington, United States

Allergy Asthma and Sinus Center-Greenfield

Greenfield, Wisconsin, United States

Consultorios Medicos Organizacion de Buen Ayre SRL

Buenos Aires, Argentina

Nexo Salud Investigacion Clinica - Riobamba 429

Buenos Aires, Argentina

CINME S.A. ? Centro de Investigaciones Metabolicas - Rx Trials LLC

Buenos Aires, Argentina

Fundacion Faicep

Buenos Aires, Argentina

Instituto de Investigaciones En Alergia Y Enfermedades Respiratorias

Buenos Aires, Argentina

AES - AS - Glenny Corp. S.A. Buenos Aires

Buenos Aires, Argentina

Centro de Medicina Respiratoria

Concepción del Uruguay, Argentina

Sanatorio de la Canada

Córdoba, Argentina

Framingham Centro Medico

La Plata, Argentina

Centro Medico Capital

La Plata, Argentina

Centro Platense en Investigaciones Respiratorias

La Plata, Argentina

Centro Medico Dharma

Mendoza, Argentina

Centro Privado de Medicina Respiratoria

Paraná, Argentina

Sala de primeros auxilios Alberto Mignaburu

Ranelagh, Berazategui, Argentina

Instituto Medico de la Fundacion Estudios Clinicos

Rosario, Argentina

Servicio de Investigacion de Patologias Alergicas-Instituto ABC

Rosario, Argentina

Sanatorio Parque de Rosario

Rosario, Argentina

Centro Modelo de Cardiologia

San Miguel de Tucumán, Argentina

Centro Medico San Nicolas Grupo Orono

San Nicolás de los Arroyos, Argentina

CEPROSS- Centro Profesional San Salvador

San Salvador, Argentina

Instituto Del Buen Aire

Santa Fe, Argentina

Centro de Diagnostico Y Rehabilitacion

Santa Fe, Argentina

Institute for Respiratory Health - Midland

Midland, South Australia, Australia

Ordination Dr. Robert Voves

Feldbach, Austria

Ordination fur Lungenkrankheiten

Linz, Austria

AZ Sint-Jan Brugge-Oostende

Bruges, Belgium

Universitair Ziekenhuis Brussel

Brussels, Belgium

Cliniques Universitaires Saint-Luc

Brussels, Belgium

CHU de Liège

Liège, Belgium

CEDOES - Diagnóstico e Pesquisa

Vitória, Espírito Santo, Brazil

L2IP ?Instituto de Pesquisas Clínicas Ltda.

Brasília, Federal District, Brazil

Santa Casa de Misericordia de Belo Horizonte - PPDS

Belo Horizonte, Minas Gerais, Brazil

Instituto Méderi de Pesquisa e Saúde

Passo Fundo, Rio Grande do Sul, Brazil

LMK Servicos Medicos SS

Porto Alegre, Rio Grande do Sul, Brazil

Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS)

Porto Alegre, Rio Grande do Sul, Brazil

Universidade Estadual Paulista Julio de Mesquita Filho Faculdade de Medicina Campus de Botucatu

Botucatu, São Paulo, Brazil

Faculdade de Medicina do ABC - FMABC

Santo André, São Paulo, Brazil

CEMEC - Centro Multidisciplinar de Estudos Clínicos

São Bernardo do Campo, São Paulo, Brazil

IBPCLIN Instituto Brasil de Pesquisa Clinica

Rio de Janeiro, Brazil

Instituto do Coracao - HCFMUSP

São Paulo, Brazil

Multiprofile Hospital for Active Treatment Puls AD PPDS

Blagoevgrad, Bulgaria

Multiprofile Hospital For Active Treatment Sveta Ekaterina - Dimitrovgrad EOOD

Dimitrovgrad, Bulgaria

Multiprofile Hospital For Active Treatment Dr. Tota Venkova JSC

Gabrovo, Bulgaria

Medical Center Hera EOOD

Montana, Bulgaria

Multiprofile Hospital for Active Treatment Plovdiv

Plovdiv, Bulgaria

Multiprofile Hospital for Active Treatment Sv. Ivan Rilski- Razgrad AD

Razgrad, Bulgaria

Multiprofile Hospital for Active Treatment Shumen

Shumen, Bulgaria

Multiprofile Hospital for Active Treatment - Silistra AD

Silistra, Bulgaria

Multiprofile Hospital For Active Treatment - Dr. Bratan Shukerov AD

Smolyan, Bulgaria

Fifth Multiprofile Hospital for Active Treatment - Sofia EAD

Sofia, Bulgaria

Diagnostic-Consultative Center Aleksandrovska EOOD

Sofia, Bulgaria

Diagnostic- Consultative Center Convex EOOD

Sofia, Bulgaria

AES DRS Medical Center Synexus Sofia EOOD

Sofia, Bulgaria

Diagnostic Consultative Centre Mladost?M OOD

Varna, Bulgaria

Medical Center Tara OOD

Veliko Tarnovo, Bulgaria

Edmonton Respiratory Consultants

Edmonton, Alberta, Canada

Office of Irvin Mayers, MD

Edmonton, Alberta, Canada

Synergy Respiratory & Cardiac Care - Synergy Wellness Centre Location

Sherwood Park, Alberta, Canada

Vancouver General Hospital

Vancouver, British Columbia, Canada

Dynamic Drug Advancement Ltd.

Ajax, Ontario, Canada

Inspiration Research

Toronto, Ontario, Canada

Dr. Syed Anees Medicine Profession Corporation

Windsor, Ontario, Canada

Dr Anil Dhar Professional Medicine Corporation

Windsor, Ontario, Canada

Recherche GCP Research

Montreal, Quebec, Canada

Clinique de pneumologie et du sommeil de Lanaudiere

Saint-Charles-Borromée, Quebec, Canada

Centre Hospitalier de l'Universite Laval

Québec, Canada

Centro Respiratorio Integral LTDA. (CENRESIN)

Pavie Gallegos, Chile

Oncocentro APYS

Viña del Mar, Chile

Fundacion Medica San Cristobal

Vitacura, Chile

The Third Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

Affiliated Hospital of Guangdong Medical University

Zhanjiang, Guangdong, China

Affiliated Hospital of Zunyi Medical University

Zunyi, Guizhou, China

The First People's Hospital of Lian Yun Gang

Lianyungang, Jiangsu, China

Beijing Chaoyang Hospital Capital Medical University

Beijing, China

China-Japan Friendship Hospital

Beijing, China

Beijing Jingmei Group General Hospital

Beijing, China

Peking University Third Hospital

Beijing, China

Beijing Hospital

Beijing, China

Peking University Shougang Hospital

Beijing, China

The First Hospital of Jilin University

Changchun, China

The First Hospital of Changsha

Changsha, China

The Third Hospital of Changsha

Changsha, China

West China Hospital, Sichuan University

Chengdu, China

Chengdu Fifth People's Hospital

Chengdu, China

The Southwest Hospital of Army Medical University

Chongqing, China

Army Medical Center of PLA(Daping Hospital)

Chongqing, China

Guangzhou First People's Hospital

Guangzhou, China

Hainan General Hospital

Haikou, China

Hangzhou First People's Hospital

Hangzhou, China

Anhui Chest Hospital

Hefei, China

Huizhou Central People's Hospital

Huizhou, China

Taizhou Hospital of Zhejiang Province

Linhai, China

Jiangxi Provincial People's Hospital

Nanchang, China

Zhongda Hospital Southeast University

Nanjing, China

Nantong First People's Hospital

Nantong, China

Jiangxi Pingxiang People's Hospital

Pingxiang, China

Huadong Hospital Affiliated to Fudan University

Shanghai, China

Shengjing Hospital of China Medical University

Shenyang, China

Tianjin Medical University General Hospital

Tianjin, China

Central Hospital of Wuhan

Wuhan, China

Wuxi People's Hospital

Wuxi, China

Jiangyin People's Hospital

Wuxi, China

Xi'an International Medical Center Hospital

Xi'an, China

Zhongshan Hospital Xiamen University

Xiamen, China

Xinxiang First People's Hospital

Xinxiang, China

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, China

Yangzhou First People?s Hospital

Yangzhou, China

The Fifth Affiliated Hospital Sun Yat-Sen University

Zhuhai, China

Zigong First People's Hospital

Zigong, China

Plicní ambulance MUDr. I. Cierná Peterová s.r.o.

Brandýs nad Labem-Stará Boleslav, Czechia

Klinika nemoci plicnich a TBC FN Brno a LF MU - Ji

Brno, Czechia

Fakultni nemocnice Hradec Kralove

Hradec Králové, Czechia

Nemocnice Kyjov, prispevkova organizace

Kyjov, Czechia

Odborna plicni ambulance Opava s.r.o

Opava, Czechia

Ordinace chorob plicních s.r.o.

Prague, Czechia

AES - DRS - Synexus Czech s.r.o.

Prague, Czechia

Nemocnice Tabor, a.s.

Tábor, Czechia

Plicni stredisko Teplice s.r.o.

Teplice, Czechia

Naestved Sygehus

Næstved, Denmark

Sjaellands Universitetshospital, Roskilde

Roskilde, Denmark

Sas Clinique De L Europe - Amiens

Amiens, France

Hopital Calmette

Lille, France

Groupe Hospitalier Cochin St Vincent de Paul La Roche Guyon

Paris, France

Hopital Haut Leveque

Pessac, France

CHU de Nancy-Hopital Brabois Adulte

Vandœuvre-lès-Nancy, France

Velocity Clinical Research Leipzig GmbH

Lübeck, Schleswig-Holstein, Germany

Praxis fur Kardiologie und Pneumologie Dr. med. Karin Forster

Berlin, Germany

Studienpraxis Berlin-Brandenburg, Berlin

Berlin, Germany

AES - DRS - Synexus Berlin Research Centre

Berlin, Germany

Lungenzentrum Darmstadt

Darmstadt, Germany

AES - DRS - Synexus Frankfurt Research Centre

Frankfurt, Germany

Universitaetsklinikum Frankfurt

Frankfurt, Germany

Clinical Research Hamburg

Hamburg, Germany

Praxisgem. Dres. Schmoller und Ehlers

Hamburg, Germany

Pneumologicum

Hanover, Germany

University Clinic Heidelberg

Heidelberg, Germany

Lungenfachklinik Immenhausen

Immenhausen, Germany

AES - DRS - Synexus Leipzig Research Centre

Leipzig, Germany

BAG Prof. Dr. G. Hoheisel Dr. A. Bonitz

Leipzig, Germany

SMO.MD GmbH

Magdeburg, Germany

Praxis Dr. med. Jan Feimer

München, Germany

Institut fur klinische Forschung GmbH

Neu-Isenburg, Germany

framol-med GmbH

Rheine, Germany

Klinikum Rosenheim

Rosenheim, Germany

University General Hospital of Alexandroupolis

Alexandroupoli, Greece

Evangelismos General Hospital of Athens

Athens, Greece

Navy Hospital of Athens

Athens, Greece

University General Hospital of Heraklion

Heraklio, Greece

University General Hospital of Ioannina

Ioannina, Greece

Iatriko Palaiou Falirou

Palaió Fáliro, Greece

Georgios Papanikolaou General Hospital of Thessaloniki

Thessaloniki, Greece

Queen Mary Hospital

Hong Kong, Hong Kong

Benyovszky Medical Center

Budapest, Hungary

Omnimodus Elixír Kft.

Csorna, Hungary

Veszprem Megyei Tudogyogyintezet

Farkasgyepű, Hungary

Paarthiv Lung Care Center

Hyderabad, Andhra Pradesh, India

Yashoda Hospitals Hitec City

Hyderabad, Andhra Pradesh, India

Government Medical College and Government General Hospital

Srikakulam, Andhra Pradesh, India

GMERS Medical College and Hospital, Sola

Ahmedabad, Gujarat, India

ESIC Medical College and Hospital - Faridabad

Faridabad, Haryana, India

Karnataka Medical College and Research Institute, Hubballi;Department of Medicine

Hubballi, Karnataka, India

Shree Hospital And Critical Care Centre

Nagpur, Maharashtra, India

Kothrud Hospital

Pune, Maharashtra, India

Aakash Healthcare Super Speciality Hospital

New Delhi, National Capital Territory of Delhi, India

Sawai Man Singh Hospital and Medical College

Jaipur, Rajasthan, India

Maharaja Agrasen Super Speciality Hospital

Jaipur, Rajasthan, India

Jawaharlal Nehru Medical College (JNMC)

Aligarh, Uttar Pradesh, India

Apollo Spectra Hospital

Kanpur, Uttar Pradesh, India

MV Hospital and Research Centre

Lucknow, Uttar Pradesh, India

Institute of Post Graduate Medical Education and Research (IPGMER) and SSKM Hospital

Kolkata, West Bengal, India

Soroka University Medical Centre

Beersheba, Israel

Rambam Medical Center - PPDS

Haifa, Israel

Lady Davis Carmel Medical Center

Haifa, Israel

Hadassah Medical Center

Jerusalem, Israel

Meir Medical Center

Kfar Saba, Israel

Presidio Ospedaliero Santa Maria della Speranza

Battipaglia, Campania, Italy

Azienda Ospedaliera Dei Colli

Napoli, Campania, Italy

Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant' Anna

Ferrara, Emilia-Romagna, Italy

Arcispedale Santa Maria Nuova

Reggio Emilia, Emilia-Romagna, Italy

Fondazione PTV Policlinico Tor Vergata

Rome, Lazio, Italy

ASST Fatebenefratelli Sacco - Ospedale Luigi Sacco

Milan, Lombardy, Italy

Fondazione IRCCS Policlinico San Matteo di Pavia

Pavia, Lombardy, Italy

Azienda Sanitaria Ospedaliera S Luigi Gonzaga

Orbassano, Piedmont, Italy

Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele

Catania, Sicily, Italy

Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

Palermo, Sicily, Italy

Azienda Ospedaliera Universitaria Careggi

Florence, Tuscany, Italy

Azienda Ospedaliero Universitaria Senese - Policlinico Santa Maria alle Scotte

Siena, Tuscany, Italy

Makita Hospital

Sapporo, Hokkaido, Japan

Miura Medical Clinic

Miura-shi, Kanagawa, Japan

Yokohama Front Clinic

Yokohama, Kanagawa, Japan

Yokohama-Gumyouji Kokyuukinaika Naika Clinic

Yokohama, Kanagawa, Japan

Matsusaka City Hospital

Matsusaka-Shi, Mie-ken, Japan

University of the Ryukyus Hospital

Ginowan-shi, Okinawa, Japan

Fujieda Municipal General Hospital

Fujieda-Shi, Shizuoka, Japan

Yamaguchi University Hospital

Ube-shi, Yamaguchi, Japan

Asahikawa Medical Center

Asahikawa-shi, Japan

Fukuoka University Chikushi Hospital

Chikushino-shi, Japan

National Hospital Organization Kyushu Medical Center

Chuo-ku, Fukuoka-shi, Japan

Fukuwa Clinic

Chūōku, Japan

Fukuoka University Hospital

Fukuoka, Japan

Nishi Fukuoka Hospital

Fukuoka-Shi Nishi-Ku, Japan

Terada Respiratory and Internal Clinic

Himeji, Japan

Hiroshima Prefectural Hospital

Hiroshima, Japan

Ishikawa Prefectural Central Hospital

Ishikawa, Japan

National Hospital Organization Minami Kyoto Hospital

Jōyō, Japan

Kagoshima Kouseiren Hospital

Kagoshima, Japan

Kagoshima University Hospital

Kagoshima, Japan

Yokohama City University Medical Center

Kanagawa, Japan

Osaka-Minami Medical Center

Kawachinagano-Shi, Japan

Kiryu Kosei General Hospital

Kiryū, Japan

Kishiwada City Hospital

Kishiwada, Japan

Hospital of the University of Occupational and Environmental Health,Japan

Kitakyushu-shi, Japan

Juntendo Tokyo Koto Geriatric Medical Center

Kōtō City, Japan

Saiseikai Kumamoto Hospital

Kumamoto, Japan

Rakuwakai Otowa Hospital

Kyoto, Japan

National Hospital Organization Kyoto Medical Center

Kyoto, Japan

Machida Municipal Hospital

Machida-shi, Japan

Dokkyo Medical University Hospital

Mibu-Machi, Japan

Fukushima Medical University Hospital

Miyagi, Japan

Nagoya Ekisaikai Hospital

Nagoya, Japan

Kojunkai Social Medical Corporation Daido Clinic

Nagoya-shi Minami-ku, Japan

National Hospital Organization Ibarakihigashi National Hospital

Naka-gun, Japan

Niigata City General Hospital

Niigata, Japan

National Hospital Organization Okayama Medical Center

Okayama, Japan

Okayama Rosai Hospital

Okayama-Shi Minami-ku, Japan

Omuta National Hospital

Omuta, Japan

Izumi City General Hospital

Osaka, Japan

Oita Medical Center

Ōita, Japan

National Hospital Organization - Sagamihara National Hospital

Sagamihara-shi Minami-ku, Japan

Sakaide City Hospital

Sakaidechō, Japan

NHO Kinki-Chuo Chest Medical Center

Sakaishi, Japan

Japan Community Health Care Organization Hokkaido Hospital

Sapporo, Japan

Idaimae Minami 4-Jo Internal Medicine

Sapporo-shi Chuo-ku, Japan

Shizuoka City Shizuoka Hospital

Shizuoka, Japan

Iwata City Hospital

Shizuoka, Japan

Kamei Internal Medicine and Respiratory Clinic

Takamatsu, Japan

National Hospital Organization Takasaki General Medical Center

Takasaki, Japan

Minami Wakayama Medical Center

Tanabe, Japan

Tokyo-Eki Center-building Clinic

Tokyo, Japan

Nihon University Itabashi Hospital

Tokyo, Japan

Japanese Red Cross Medical Center

Tokyo, Japan

Toyama Prefectural Central Hospital

Toyama, Japan

Yamagata University Hospital

Yamagata, Japan

Nagata Hospital

Yanagawa, Japan

Showa University Fujigaoka Hospital

Yokohama-shi Aoba-ku, Japan

Kanagawa Cardiovascular and Respiratory Center

Yokohama-shi Kanazawa-ku, Japan

National Hospital Organization - Yokohama Medical Center

Yokohama-Shi Totsuka-Ku, Japan

Sanyudo Hospital

Yonezawa, Japan

KEMRI-MTWAPA Clinical Trial Site

Kilifi, Coast, Kenya

Clinical Research Health Network (CREA-N)

Machakos, Kenya

KEMRI CRDR Clinical Research Clinic Nairobi

Nairobi, Kenya

University of Nairobi Clinical Research Centre

Nairobi, Kenya

KEMRI/CRDR Siaya Clinical Research Annex

Siaya, Kenya

Center for Research In Tropical Medicine and community development

Thika, Kenya

Health Center Association, Medical Center OLVI

Daugavpils, Latvia

Daugavpils Regional Hospital

Daugavpils, Latvia

Pauls Stradins Clinical University Hospital

R?ga, Latvia

Riga 1st Hospital

Riga, Latvia

ConsiliumMedicum

Riga, Latvia

Postgraduate Medical Training Institute University of Latvia

Riga, Latvia

Meander Medisch Centrum

Amersfoort, Netherlands

Martini Ziekenhuis

Groningen, Netherlands

Zuyderland Medisch Centrum - Heerlen

Heerlen, Netherlands

Greenlane Clinical Centre

Auckland, New Zealand

Dunedin Hospital

Dunedin, New Zealand

Waikato Hospital

Hamilton, New Zealand

P3 Research

Tauranga, New Zealand

P3 Research - Kapiti - PPDS

Waikanae Beach, New Zealand

Manila Central University-Filemon D Tanchoco Medical Foundation

Caloocan, Philippines

CARE CT Group Inc.

Dasmariñas, Philippines

Healthlink Medicalsurgicaldental Clinic and Diagnostic Center

Iloilo City, Philippines

West Visayas State University Medical Center

Iloilo City, Philippines

Mary Mediatrix Medical Center

Lipa City, Philippines

Philippine Heart Center

Quezon City, Philippines

Quirino Memorial Medical Center

Quezon City, Philippines

CenterMed Sp. z o.o.

Tarnów, Lesser Poland Voivodeship, Poland

AppleTreeClinics Network Sp. z o.o.

Lodz, Lódzkie, Poland

Centrum Medycyny Oddechowej Mroz sp. j.

Bia?ystok, Poland

Vitamed Galaj i Cichomski sp.j.

Bydgoszcz, Poland

Medical Center Kermed

Bydgoszcz, Poland

Centrum Medyczne Lukamed Joanna Luka-Wendrowska

Chojnice, Poland

AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Czestochowie

Częstochowa, Poland

AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Gdansku

Gda?sk, Poland

Synexus Polska Sp. z o.o. Oddzial w Gdyni

Gdynia, Poland

Centrum Medyczne CLW-med Aneta Cichomska , Joanna Luka -Wendrowska

Grudzadz, Poland

Prywatny Gabinet Pulmonologiczny Joanna Nowacka-Apiyo

Grudziądz, Poland

Centrum Medyczne Katowice - PRATIA - PPDS

Katowice, Poland

Wojewodzki Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie

Krakow, Poland

Prywatna Praktyka Lekarska Adam Smialowski

Ksawerów, Poland

AES - DRS - Synexus Polska Sp. Z o.o. Oddzial w Lodzi

Lodz, Poland

Clinical Best Solutions - Lublin

Lublin, Poland

NZOZ Przychodnia Alergologiczno-pulmonologiczna

Lublin, Poland

ABC-Pulmo NZOZ Agnieszka Dobielska, Jaroslaw Dobie

Radom, Poland

Centrum Medyczne KARDIOTEL

Sopot, Poland

Kiepury Clinic

Sosnowiec, Poland

Gabinet Pulmonologii i Diagnostyki Chorob Alergicznych Dorota Malosek

Szczecin, Poland

NZOZ Poradnia Chorob Pluc i Alergologii

Słupsk, Poland

MICS Centrum Medyczne Torun

Torun, Poland

Viltis Medica Specjalistyczna Praktyka Lekarska Lek. Med. Agata Kot

Trzebnica, Poland

AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Warszawie

Warsaw, Poland

Synexus Polska Sp. z o.o. Oddzial we Wroclawiu

Wroc?aw, Poland

Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska

Wroc?aw, Poland

Lekarze Specjalisci J. Malolepszy i Partnerzy

Wroc?aw, Poland

Medical Center Clinhouse

Zabrze, Poland

Allianze Pulmonary Research LLC

Guaynabo, Puerto Rico

Cardos Rosca Medical S.R.L.

Cluj-Napoca, Romania

Fundatia CardioPrevent

Timișoara, Romania

Iatros International

Bloemfontein, Free State, South Africa

Newtown Clinical Research Centre

City of Johannesburg, Gauteng, South Africa

Johese Clinical Research

Centurion, South Africa

Dr. Ismail Abdullah Private Practice

City of Cape Town, South Africa

CLINRESCO, ARWYP Medical Suites

Kempton Park, South Africa

Ubuntu Clinical Research Sites

Krugersdorp, South Africa

AES - DRS - Synexus Watermeyer Clinical Research Centre

Pretoria, South Africa

Medicross Pretoria West, Jongaie Research

Pretoria, South Africa

AES - DRS - Synexus - Helderberg Clinical Research Centre

Somerset West, South Africa

Dr Yacoob AK Private Practice

Welkom, South Africa

Soon Chun Hyang University Hospital Bucheon

Bucheon-si, South Korea

Chungbuk National University Hospital

Cheongju-si, South Korea

Yeungnam University Hospital

Daegu, South Korea

CHA Bundang Medical Center

Gyeonggi-do, South Korea

Kangbuk Samsung Hospital

Seoul, South Korea

Asan Medical Center - PPDS

Seoul, South Korea

Samsung Medical Center - PPDS

Seoul, South Korea

Chung-Ang University Hospital

Seoul, South Korea

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, South Korea

Yonsei University Wonju Severance Christian Hospital

Wŏnju, South Korea

Hospital Universitario Son Espases

Palma de Mallorca, Balearic Islands, Spain

Hospital El Bierzo

Ponferrada, LEON, Spain

Hospital Universitario de Torrejon

Torrejón de Ardoz, Madrid, Spain

Vithas Xanit International Hospital

Benalmádena Costa, Malaga, Spain

Hospital del Mar

Barcelona, Spain

Hospital Universitario La Paz - PPDS

Barcelona, Spain

Hospital Universitario de La Princesa

Madrid, Spain

Hospital Universitario Virgen del Rocio

Seville, Spain

Hospital Clinico Universitario de Valencia

Valencia, Spain

Consorcio Hospital General Universitario de Valencia

Valencia, Spain

Hospital de La Ribera

Valencia, Spain

Clinical Trial Consultants - Linkoping

Uppsala, Uppsala County, Sweden

Sahlgrenska Universitetssjukhuset

Gothenburg, Sweden

Universitetssjukhuset Orebro (USO)

Örebro, Sweden

Clinical Trial Consultants - Karolinska

Solna, Sweden

Akardo AB

Stockholm, Sweden

Clinical Trial Consultants - Uppsala

Uppsala, Sweden

Zurcher Reha Zentren Wald

Zurich, Switzerland

Changhua Christian Hospital

Chang-hua, Taiwan

Kaohsiung Medical University Hospital

Kaoshiung City, Taiwan

Far East Memorial Hospital

New Taipei City, Taiwan

Taipei Medical University Hospital

Taipei, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

Tri-Service General Hospital

Taipei, Taiwan

Chang Gung Memorial Hospital - Linkou

Taoyuan District, Taiwan

Chulalongkorn University

Bangkok, Thailand

Srinagarind Hospital, Khon Kaen University

Khon Kaen, Thailand

Central Chest Institute of Thailand

Muang, Thailand

Sureyyapasa Gogus Hastaliklari ve Gogus Cerrahisi Egitim ve Arastirma Hastanesi

Istanbul, Turkey (Türkiye)

Kocaeli University Hospital

Kocaeli, Turkey (Türkiye)

Kirikkale Universitesi Tip Fakultesi Hastanesi

Kırıkkale, Turkey (Türkiye)

Mersin University Medical Faculty

Mersin, Turkey (Türkiye)

Rize Recep Tayyip Erdogan University Training and Research Hospital

Rize Merkez, Turkey (Türkiye)

Cukurova Universitesi Tip Fakultesi Balcali Hastanesi

Sarıçam, Turkey (Türkiye)

Castle Hill Hospital

Cottingham, Yorkshire, United Kingdom

AES - DRS - Synexus Scotland Clinical Research Centre

Bellshill, United Kingdom

AES - DRS - Synexus Midlands Clinical Research Centre

Birmingham, United Kingdom

AES - DRS - Synexus Wales Clinical Research Centre

Cardiff, United Kingdom

Royal Primary Care - Ashgate Manor

Chesterfield, United Kingdom

AES - DRS - NW Consortium Lancashire

Chorley, United Kingdom

Lakeside Surgery

Corby, United Kingdom

University Hospital Coventry

Coventry, United Kingdom

Royal Infirmary of Edinburgh

Edinburgh, United Kingdom

AES - DRS - Synexus Hexham Clinical Research Centre

Hexham, United Kingdom

Velocity Clinical Research - High Wycombe - PPDS

High Wycombe, United Kingdom

Royal Lancaster Infirmary

Lancaster, United Kingdom

St James University Hospital

Leeds, United Kingdom

Glenfield Hospital

Leicester, United Kingdom

AES - DRS - NW Consortium Merseyside

Liverpool, United Kingdom

Velocity Clinical Research North London - Percy Road - PPDS

London, United Kingdom

St Thomas' Hospital

London, United Kingdom

AES - DRS - NW Consortium Manchester

Manchester, United Kingdom

Norfolk and Norwich University Hospital

Norwich, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT05595642


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