RecruitingNCT05596539
Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)
Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia
Sponsor
Assistance Publique - Hôpitaux de Paris
Enrollment
130 participants
Start Date
Mar 22, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to assess medical events during follow-up of adult patients having hypophosphatasia and consulting rheumatologists.
Eligibility
Min Age: 18 Years
Inclusion Criteria3
- men and women,
- aged 18 and over, with no upper age limit, who have had a total alkaline phosphatase value of less than 40 IU/l on at least 3 occasions, or at least a total alkaline phosphatase value below 40 IU/L and evidence of ALPL gene polymorphism
- with at least one rheumatological symptom.
Exclusion Criteria2
- transient hypophosphatasia: absence of confirmation of a value below 40 IU/l on at least 3 samples, lack of genetic confirmation
- secondary hypophosphatasia according to the expert rheumatologist (drugs, endocrine disease, other genetic disease...).
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Interventions
OTHERData collection
Collection data from diagnostic Data collected following to medical exam as part of care
Locations(11)
View Full Details on ClinicalTrials.gov
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NCT05596539
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