RecruitingNot ApplicableNCT05599139

Iodine Uptake After a Low Iodine Diet

The Uptake of Radioactive Iodine Before and After a Low Iodine Diet in Patients With Differentiated Thyroid Carcinoma


Sponsor

University Medical Center Groningen

Enrollment

25 participants

Start Date

Feb 22, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to compare the difference in thyroid uptake of a low dose radioactive iodine (10 MBq 123-I or 37 MBq 123-I) in athyreotic patients with differentiated thyroid carcinoma before and after a low iodine diet (LID) of 7 days. The main question it aims to answer is: • What is the difference in iodine uptake before and after a LID of 7 days? Uptake of a low dose of 123-iodine will be measured in participants before and after a low iodine diet of 7 days. Researchers will compare the uptake (%) before and after the LID.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study looks at how well radioactive iodine (I-131) is absorbed by the thyroid after patients with thyroid cancer follow a low-iodine diet. It aims to better understand whether this diet actually improves the effectiveness of post-surgery radioiodine treatment. **You may be eligible if...** - You have been diagnosed with differentiated thyroid cancer (DTC) - You are following a low-iodine diet before your radioiodine ablation therapy as part of your standard treatment - You are 18 or older - You can read and understand Dutch **You may NOT be eligible if...** - You are under 18 years old - You are currently taking amiodarone (a heart medication that contains a lot of iodine) - You have kidney problems that affect iodine clearance Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALLow iodine diet

Before ablation and possible subsequent therapy with 131I, patients have to follow a low iodine diet (LID), reducing the iodine intake \< 50 mcg per day and thereby depleting the overall iodine store in the body.


Locations(1)

UMCG

Groningen, Provincie Groningen, Netherlands

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NCT05599139


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