Iodine Uptake After a Low Iodine Diet
The Uptake of Radioactive Iodine Before and After a Low Iodine Diet in Patients With Differentiated Thyroid Carcinoma
University Medical Center Groningen
25 participants
Feb 22, 2023
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to compare the difference in thyroid uptake of a low dose radioactive iodine (10 MBq 123-I or 37 MBq 123-I) in athyreotic patients with differentiated thyroid carcinoma before and after a low iodine diet (LID) of 7 days. The main question it aims to answer is: • What is the difference in iodine uptake before and after a LID of 7 days? Uptake of a low dose of 123-iodine will be measured in participants before and after a low iodine diet of 7 days. Researchers will compare the uptake (%) before and after the LID.
Eligibility
Inclusion Criteria3
- Patients, men and women above the age of 18 years, have to be diagnosed with DTC and have to follow a LID prior to the 131I ablation therapy according to the Dutch DTC guideline
- Patients have to be fit to adhere to the study protocol
- Patients have to be able to read and understand the Dutch language
Exclusion Criteria6
- Age \< 18 years
- Patients using amiodarone
- Patients receiving iodinated contrast \< 3 months before the LID
- Pregnancy
- Patients prepared for ablation therapy with rhTSH
- Renal impairment, EGFR \<30ml/min/1,73m2
Interventions
Before ablation and possible subsequent therapy with 131I, patients have to follow a low iodine diet (LID), reducing the iodine intake \< 50 mcg per day and thereby depleting the overall iodine store in the body.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05599139