De-escalated Radiation for Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx

This study tests whether a reduced (de-escalated) dose of radiation therapy works just as well as the standard dose for patients with HPV-positive throat cancer (oropharyngeal squamous cell carcinoma). Since HPV-positive cancers respond well to treatment, using less radiation may cause fewer long-term side effects while keeping the same cure rate. **You may be eligible if...** - You have been diagnosed with HPV-positive squamous cell carcinoma of the throat (oropharynx), confirmed by biopsy - Your cancer is p16-positive (a marker for HPV) - Your cancer is at an appropriate stage for this approach - You have not yet received radiation for this cancer **You may NOT be eligible if...** - Your throat cancer is HPV-negative - You have had previous radiation to the head or neck area - Your cancer has spread to distant organs (metastatic) - You have serious health conditions that make radiation treatment risky Talk to your doctor to see if this trial is right for you.