RecruitingNot ApplicableNCT05603650

Effects of Mouthrinse on the Microbiome of the Oral Cavity and GI Tract

Effects of Mouthrinses on the Microbiome of the Oral Cavity and GI Tract


Sponsor

University of California, Irvine

Enrollment

200 participants

Start Date

Sep 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this research study is to identify the effects of 2 over-the-counter mouthwashes on bacteria and 3 viruses in the participant's mouth and gut. The participant will be randomly allocated to rinse their mouth twice daily either with Listerine mouthwash, Lumineux Oral Essentials mouthwash, or water. The overall duration of the study will be approximately 180 days and will include approximately 5 visits and 15-30 minutes for each visit with a total of approximately 2.5 hours of your time. Additionally, fecal matter will also be collected in some subjects using a commercial collection kit.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates how using mouthrinse affects the bacteria living in the mouth and gut (the microbiome). Researchers want to know if regular use of mouthwash changes the balance of these bacteria, which could have broader health implications. You may be eligible if: - You are 18 to 25 years old - You are male, or a non-pregnant, non-breastfeeding female of any race - You have at least 20 teeth (not counting wisdom teeth) - You are willing to attend all scheduled visits and be available for phone follow-up - Your gums are either healthy or bleed when you brush You may NOT be eligible if: - You have fewer than 20 teeth - You have taken antibiotics in the past 3 months - You are unable or unwilling to sign the consent form - You have a condition that the investigator believes would interfere with the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERLumineux Oral Essentials rinse

mouthrinse

OTHERListerine rinse

mouthrinse


Locations(1)

Beckman Laser Institute and Medical Clinic

Irvine, California, United States

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NCT05603650


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