PRIME: PReservIng Memory in Epilepsy
Network Neuro-modulation for Mesial Temporal Lobe Epilepsy
Nitin Tandon
8 participants
Nov 16, 2023
INTERVENTIONAL
Conditions
Summary
In this study, participants will receive unilateral Deep Brain Stimulation (DBS) for treatment of epilepsy, with network-based stimulation targets specifically defined using a stereo-electro-encephalographic evaluation and chronic recordings using the Medtronic Percept™ primary cell (PC) Neurostimulator DBS System with BrainSense™ Technology. The hypothesis is that, compared to no stimulation or to standard duty cycle high frequency stimulation, epilepsy neuromodulation using low frequency stimulation and informed by network architecture in patients with epilepsy that arises in a hippocampus that also subserves memory - epilepsy in a precious hippocampus (EPH) - will result in a significant decrease in seizure frequency and severity, paralleled by a decrease in EEG spike counts and improved memory function.
Eligibility
Plain Language Summary
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Interventions
Stimulation of site with the Medtronic Percept PC system using low frequency stimulation at 0.5 Hz.
Stimulation of the Anterior Nucleus of the Thalamus (ANT) with the Medtronic Percept PC system using standard of care high frequency stimulation parameters.
Locations(2)
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NCT05608408