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RecruitingNCT05609123

Endothelial Glycocalyx Damage in Brain Death Organ Donors

Endothelial Glycocalyx Status and Damage in Brain Death Organ Donors

Sponsor

University Hospital Hradec Kralove

Enrollment

100 participants

Start Date

Jan 1, 2022

Study Type

OBSERVATIONAL

Conditions

Brain Damage Due to HypoxiaOrgan DonorsOrgan Transplant Failure or Rejection

Summary

The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • patients in critical condition declared as brain dead by clinical examination

Exclusion Criteria1

  • N/A

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Interventions

DIAGNOSTIC_TESTEndothelial glycocalyx damage assessment

Degradation products of endothelial glycocalyx will be assessed in the blood and urine.

Locations(1)

University Hospital Hradec Kralove

Hradec Králové, Czechia

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NCT05609123