Concomitant Hybrid Versus Catheter Ablation for Atrial Fibrillation With Hypertrophic Cardiomyopathy

This study compares two ways of treating an irregular heart rhythm called persistent atrial fibrillation (AF) in people who also have hypertrophic cardiomyopathy (HCM) — a condition where the heart muscle is abnormally thick. The two approaches are: a minimally invasive hybrid surgery, and catheter ablation alone. **You may be eligible if...** - You are 18 or older - You have been diagnosed with hypertrophic cardiomyopathy (heart muscle wall ≥ 15 mm or ≥ 13 mm if genetic mutation confirmed) - Your left ventricular outflow is not obstructed (peak gradient under 30 mmHg) - You have persistent atrial fibrillation lasting between 7 days and 3 years **You may NOT be eligible if...** - You have obstructive HCM with significant outflow obstruction - Your atrial fibrillation lasted less than 7 days or more than 3 years - You have other serious cardiac or health conditions (check full criteria with your doctor) Talk to your doctor to see if this trial is right for you.