RecruitingNot ApplicableNCT05612347

Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Colonoscopy Versus Stool-based Testing for Older Adults With a History of Colon Polyps

Sponsor

Dartmouth-Hitchcock Medical Center

Enrollment

8,946 participants

Start Date

Jun 14, 2023

Study Type

INTERVENTIONAL

Conditions

Colorectal Neoplasms Colorectal Polyp Colorectal Adenoma

Summary

This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.

Eligibility

Min Age: 65 YearsMax Age: 82 Years

Plain Language Summary

Simplified for easier understanding

This study compares two options for older adults who have had small colon polyps removed: a follow-up colonoscopy versus a stool-based test — to see which is equally effective and easier for patients. You may be eligible if: - You speak English or Spanish - You have a personal history of colon polyps - Your most recent colonoscopy found 2 or fewer small, non-advanced polyps - You are currently due (or coming due within 12 months) for a follow-up colonoscopy - You are able and willing to provide informed consent You may NOT be eligible if: - You have a personal history of colorectal cancer - You have Lynch Syndrome, Familial Adenomatous Polyposis (FAP), or another hereditary condition raising your colon cancer risk - You have inflammatory bowel disease (like ulcerative colitis or Crohn's disease) - Your last colonoscopy found advanced polyps, or 3 or more polyps - You have serious health problems that make colon cancer screening unlikely to benefit you (such as recent heart surgery, heart failure, severe lung disease, recent stroke, advanced dementia, severe liver or kidney disease, or a new cancer diagnosis in the past year) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTFIT

Annual FIT

DIAGNOSTIC_TESTColonoscopy

One time surveillance colonoscopy

Locations(19)

University of Alabama Birmingham

Birmingham, Alabama, United States

University of Arizona

Tucson, Arizona, United States

Kaiser Permanente Northern California

Walnut Creek, California, United States

University of Colorado

Aurora, Colorado, United States

MedStar Health

Washington D.C., District of Columbia, United States

James A. Haley Veterans Hospital

Tampa, Florida, United States

Northwestern Memorial Hospital

Chicago, Illinois, United States

University of Chicago

Chicago, Illinois, United States

Rockford Gastroenterology Associates

Rockford, Illinois, United States

Richard L. Roudebush VA Medical Center

Indianapolis, Indiana, United States

University of Michigan Health

Ann Arbor, Michigan, United States

Dartmouth Health

Lebanon, New Hampshire, United States

New York Harbor Health Care System - Dept of Veterans Affairs

New York, New York, United States

Kaiser Permanente Northwest

Portand, Oregon, United States

Oregon Health & Science University (Knight Cancer Institute)

Portland, Oregon, United States

Intermountain Health

Sandy City, Utah, United States

University of Virginia Health

Charlottesville, Virginia, United States

University of British Columbia

Vancouver, British Columbia, Canada

University of Manitoba

Winnipeg, Manitoba, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT05612347

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