Improve Outcomes for Older Allogeneic Transplant Recipients
Intervening on Frailty to Improve Outcomes for Older Allogeneic Transplant Recipients
Abramson Cancer Center at Penn Medicine
72 participants
Feb 15, 2023
INTERVENTIONAL
Conditions
Summary
This is an interventional pilot study to determine whether implementation of a supervised exercise program can improve outcomes in subjects undergoing allogeneic HCT. The primary objective is to determine feasibility. Up to 60-72 evaluable subjects will be enrolled. Evaluable subjects are defined as those participating in the exercise intervention.
Eligibility
Inclusion Criteria9
- Cohort A (Prehab)
- Age 60 years or older.
- Planned allogeneic HCT in the next 1-6 months.
- Hematological malignancy as the indication for HCT.
- Pre-frail or frail by Fried frailty phenotype.
- Cohort B (Rehab)
- Age 60 years or older.
- Planned allogeneic HCT or HCT within the last 30 days.
- Hematological malignancy as the indication for HCT.
Exclusion Criteria2
- Cohorts A and B
- \. Comorbid disability or illness that prevents safe exercise.
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Interventions
Pre-frail and frail potential HCT recipients 60 years and older will participate in a supervised exercise program from the time of enrollment up until HCT admission. Exercise compliance will be measured in part through physical activity trackers.from time of discharge from HCT until day +100 post-HCT. All HCT recipients 60 years and older will participate in a supervised exercise program from the time of discharge from HCT admission until day +100 post-HCT. Exercise compliance will be measured in part through physical activity trackers.
All HCT recipients 60 years and older will participate in a supervised exercise program from the time of discharge from HCT admission until day +100 post-HCT. Exercise compliance will be measured in part through physical activity trackers.
Locations(1)
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NCT05612789