RecruitingNot ApplicableNCT05617872

Vinegar-induced Collection of Duodenal Pancreatic Juice Via Endoscopic Ultrasound


Sponsor

Peking Union Medical College Hospital

Enrollment

75 participants

Start Date

Dec 30, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn about the feasibility of collecting pancreatic juice through duodenal aspiration by ultrasound endoscopy (EUS) for molecular marker testing after intraduodenal infusion of vinegar in patients with suspected pancreatic cancer and who are scheduled to have endoscopic ultrasound with fine needle aspiration (EUS-FNA). The main questions it aims to answer are: * Is vinegar-induced collection of duodenal pancreatic juice via endoscopic ultrasound feasible? * What is the best operating condition (amount of vinegar, collection time, etc.) of vinegar-induced collection of duodenal pancreatic juice via endoscopic ultrasound? Participants will have EUS as scheduled, during which different amount of vinegar will be infused into duodenum and then pancreatic juice be collected for different time via suction by EUS. Researchers will compare the amount of collected pancreatic juice and molecular marker level in different groups to determine the best operating condition for vinegar-induced collection of duodenal pancreatic juice via endoscopic ultrasound.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether giving vinegar before an endoscopic ultrasound procedure can stimulate the pancreas to produce juice that contains cancer cells, making it easier to diagnose pancreatic cancer without always needing a biopsy needle. **You may be eligible if...** - You are 18 or older - An imaging scan (CT, MRI, or ultrasound) shows a mass in your pancreas that three endoscopists agree is likely pancreatic cancer - Your doctor has recommended an endoscopic ultrasound with biopsy (EUS-FNA) to plan your further treatment - You understand the study and can provide written consent **You may NOT be eligible if...** - Three endoscopists do not agree your imaging suggests pancreatic cancer - You have refused the biopsy procedure - Your general health or the need for anesthesia makes the procedure unsafe - Your imaging shows severe blockage of your pancreatic duct - You are unable to understand the study or are unwilling to participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGVinegar 20ml

Inject 20ml vinegar (5% acetic acid solution) into duodenum and collect the pancreatic juice for 15 minutes via EUS, changing the collection bottle every 5 minutes.

DRUGSaline (NaCl 0,9 %) (placebo)

Inject 20ml normal saline solution into duodenum and collect the pancreatic juice for 15 minutes via EUS, changing the collection bottle every 5 minutes.

DRUGVinegar 40ml

Inject 40ml vinegar (5% acetic acid solution) into duodenum and collect the pancreatic juice for 15 minutes via EUS, changing the collection bottle every 5 minutes.


Locations(1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

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NCT05617872


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