RecruitingNot ApplicableNCT05626608

Continuous Electrical Neuromodulation of the Globus Pallidus Intern in Parkinson's Disease by the Directional Electrode CARTESIA™

Neuromodulation électrique Continue du Globus Pallidus Dans la Maladie de Parkinson Par l'électrode Directionnelle CARTESIA™


Sponsor

University Hospital, Montpellier

Enrollment

10 participants

Start Date

Apr 28, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Many patients have benefited from the implantation of brain stimulation electrodes for the treatment of various motor signs of Parkinson's disease in the phase of motor fluctuations. This technique has significantly improved the motor symptomatology of Parkinson's disease and the dyskinesias induced by pharmacological treatment. Technological advances in the field of deep brain stimulation (DBS) could improve the benefit of this therapeutic tool. therapeutic tool. While using directional electrodes, it remains possible to program the stimulation in conventional ring mode.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a directional deep brain stimulation (DBS) device called CARTESIA to treat Parkinson's disease. DBS involves surgically implanting a small device that delivers electrical pulses to a specific area deep in the brain, helping control movement symptoms like tremor, stiffness, and slowness. **You may be eligible if...** - You have a diagnosis of bilateral idiopathic Parkinson's disease that has been progressing for more than 4 years - Your symptoms still respond well to levodopa (L-Dopa) medication, with at least 30% improvement on a standard motor scale - You have significant motor problems such as prolonged freezing episodes, fluctuating symptoms, or disabling tremor that is not adequately controlled by medication - Your general health allows you to undergo surgery and general anesthesia **You may NOT be eligible if...** - You have significant depression, psychosis, or dementia - You have a pacemaker, cochlear implant, or other device that is incompatible with MRI - You have metal implants in the brain or contraindications to surgery - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEClassical ring stimulation

Unilateral or bilateral subthalamic nucleus stimulation in the treatment of Parkinson's disease using Boston Cartesia(TM) electrodes

DEVICEStimulation in directional mode

Directional stimulation of the subthalamic nucleus in the treatment of Parkinson's disease using Boston Cartesia(TM) electrodes


Locations(1)

Centre Hospitalier Uniersitaire de Montpellier

Montpellier, France, France

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NCT05626608


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