Disulfiram for Treatment of Retinal Degeneration

This study is testing whether disulfiram, a medication normally used for alcohol dependence, can slow down or halt vision loss in people with inherited retinal degeneration — a group of genetic eye conditions that progressively destroy the light-sensing cells in the retina. Researchers believe disulfiram may protect retinal cells through a different biological mechanism. Participants must be willing and able to completely avoid alcohol during and around the time of the study. You may be eligible if: - You are 18 years of age or older - You have a clinical (and ideally genetic) diagnosis of inherited retinal degeneration - Your best corrected vision in the study eye is 20/40 or better - Your visual field is constricted to 10 degrees centrally - Your liver function tests are within normal limits - You are willing to completely abstain from alcohol for the duration of the study and the 2 weeks before and after You may NOT be eligible if: - You have alcohol dependence, cardiovascular disease, or hepatitis - You have a history of diabetes, psychosis, or hypothyroidism - You have a known allergy to thiuram derivatives (found in certain rubber products) - You are taking blood thinners or other medications that interact with disulfiram - You have other eye conditions affecting your vision beyond the retinal degeneration - You have had major eye surgery within the past 6 months - You are pregnant, breastfeeding, or planning to become pregnant Talk to your doctor to see if this trial is right for you.