Best Antithrombotic Therapy in Patients With Acute Venous ThromboEmbolism While Taking Antiplatelets

This study is investigating the best combination of blood-thinning medications for people who develop an acute blood clot (venous thromboembolism, or VTE) while already taking antiplatelet medications for heart or vascular disease. When these patients get a DVT or pulmonary embolism, it's unclear whether they should stop the antiplatelet drug, continue it alongside anticoagulation, or adjust one of the treatments. This trial aims to find the safest and most effective combination. You may be eligible if: - You are 18 years of age or older - You have been diagnosed with an acute deep vein thrombosis (DVT) in a major leg vein or a pulmonary embolism (PE) - You need at least 3 months of full anticoagulation therapy - You are already taking antiplatelet medications (such as aspirin or clopidogrel) for a cardiovascular condition like heart disease or stroke prevention - You have a life expectancy greater than 3 months You may NOT be eligible if: - You have active or high-risk bleeding that makes anticoagulation unsafe - Your blood pressure is severely elevated (above 180/110 mmHg) - You have been on anticoagulation for more than 5 days before enrollment - You are pregnant or planning to become pregnant - You only have an isolated clot in a small distal vein - You are taking antiplatelet drugs for primary (not secondary) cardiovascular prevention - You have had a major heart attack, stroke, or vascular event in the past 6–12 months Talk to your doctor to see if this trial is right for you.