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RecruitingNCT05634200

Utility of Bronchoscopy in Patients With Haemoptysis and Negative Chest CT Scan (ULYSSES)

Utility of Bronchoscopy in Patients With Haemoptysis and Negative Chest CT Scan: an Observational, Prospective, Multicentre Study (ULYSSES)

Sponsor

University of Milan

Enrollment

150 participants

Start Date

Oct 1, 2022

Study Type

OBSERVATIONAL

Conditions

Hemoptysis

Summary

Conflicting evidence exist in the literature on the utility of bronchoscopy in patients with haemoptysis and negative/non-diagnostic chest CT scan. The primary aim of this prospective, observational, multicenter study is to evaluate the utility of bronchoscopy in patients with haemoptysis and negative/non-diagnostic CT scans. Secondary aims are related to the utility of bronchoscopy to detect occult malignancies, the source of the bleeding and the clinical features of the cohort

Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • ≥18 years old
  • Haemoptysis of unknown origin
  • Negative or non-diagnostic chest CT scan

Exclusion Criteria4

  • Known bleeding lesions of the upper or lower respiratory airways
  • Chest CT scan diagnostic for hemoptysis etiology
  • Refusal to sign the informed consent
  • Refusal of bronchoscopy

Interventions

PROCEDUREBronchoscopy

During bronchoscopy endobronchial biopsy, transbronchial biopsy, transbronchial needle aspiration, bronchial washing, bronchoalveolar lavage, EBUS-TBNA and EUS-B-FNA may be performed

Locations(14)

- Respiratory Unit, ASST Papa Giovanni XVIII

Bergamo, Italy

- Interventional Pulmonology Unit, Policlinico S. Orsola-Malpighi

Bologna, Italy

Department of Pulmonary and Critical Care Medicine, Sant'Anna Hospital

Como, Italy

Respiratory Unit, ASST Lodi

Lodi, Italy

Respiratory Unit, ASST Santi Paolo e Carlo

Milan, Italy

- Respiratory Unit, Sacco Hospital, ASST Fatebenefratelli-Sacco

Milan, Italy

Respiratory Unit, San Gerardo Hospital, ASST Monza

Monza, Italy

Interventional Pulmonology Unit, Dept of Pulmonology, Oncology and Hematology, Cardarelli Hospital

Naples, Italy

- Respiratory Unit, IRCCS Foundation Policlinico San Matteo

Pavia, Italy

Pulmonology Unit, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia

Reggio Emilia, Italy

- Interventional Pulmonology Unit, Policlinico Agostino Gemelli

Roma, Italy

- Respiratory Unit, A.O.U. Città della Salute e della Scienza di Torino

Torino, Italy

Department of Pulmonology, University Hospital of Udine (ASUFC)

Udine, Italy

Interventional Pulmonology Unit, Respiratory Department, University Hospital Santa Creu i Sant Pau

Barcelona, Spain

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NCT05634200