RecruitingPhase 1NCT05636111

Phase 1b of Lurbinectedin in Combination With Weekly Paclitaxel and Bevacizumab in Platinum-resistant Ovarian Cancer


Sponsor

M.D. Anderson Cancer Center

Enrollment

34 participants

Start Date

Jul 12, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

To learn if adding lurbinectedin to the combination of paclitaxel and bevacizumab can help to control advanced cancer.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial tests a combination of three drugs — lurbinectedin, weekly paclitaxel (a chemotherapy), and bevacizumab (a targeted drug that blocks tumor blood supply) — in women with ovarian cancer that stopped responding to platinum-based chemotherapy. **You may be eligible if...** - You are 18 years or older - You have ovarian cancer that is resistant to platinum chemotherapy (meaning prior platinum treatment did not work or stopped working) - You are able to tolerate and comply with the treatment schedule **You may NOT be eligible if...** - Your ovarian cancer still responds to platinum-based chemotherapy - You cannot comply with the study visits and procedures - You have certain other health conditions that make the combination unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPaclitaxel

Given by (IV) vein

DRUGBevacizumab

Given by (IV) vein

DRUGLurbinectedin

Given by (IV) vein


Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

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NCT05636111


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