RecruitingPhase 1NCT05636111
Phase 1b of Lurbinectedin in Combination With Weekly Paclitaxel and Bevacizumab in Platinum-resistant Ovarian Cancer
Sponsor
M.D. Anderson Cancer Center
Enrollment
34 participants
Start Date
Jul 12, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
To learn if adding lurbinectedin to the combination of paclitaxel and bevacizumab can help to control advanced cancer.
Eligibility
Sex: FEMALEMin Age: 18 Years
Plain Language Summary
Simplified for easier understanding
This trial tests a combination of three drugs — lurbinectedin, weekly paclitaxel (a chemotherapy), and bevacizumab (a targeted drug that blocks tumor blood supply) — in women with ovarian cancer that stopped responding to platinum-based chemotherapy.
**You may be eligible if...**
- You are 18 years or older
- You have ovarian cancer that is resistant to platinum chemotherapy (meaning prior platinum treatment did not work or stopped working)
- You are able to tolerate and comply with the treatment schedule
**You may NOT be eligible if...**
- Your ovarian cancer still responds to platinum-based chemotherapy
- You cannot comply with the study visits and procedures
- You have certain other health conditions that make the combination unsafe
Talk to your doctor to see if this trial is right for you.
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DRUGPaclitaxel
Given by (IV) vein
DRUGBevacizumab
Given by (IV) vein
DRUGLurbinectedin
Given by (IV) vein
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05636111
Related Trials
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
NCT0548921196 locations
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
NCT0512348267 locations
Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer
NCT063214842 locations
ASk Questions in GYnecologic Oncology (ASQ-GYO)
NCT063398271 location
Pilot Randomized Controlled Trial of a Collaborative Agenda-setting Intervention (CASI) for Patients With Ovarian Cancer
NCT065435371 location