RecruitingPhase 2NCT05636787

Clinical Trial Investigating the Chemotherapeutic Compound Treosulfan (Trecondi® Ideogen) in Myeloma Patients

A Randomized Phase II Trial Comparing Treosulfan and Melphalan With Melphalan Alone as Conditioning Regimen for Autologous Stem Cell Transplantation (ASCT) in Myeloma Patients (TreoMel Trial)


Sponsor

Insel Gruppe AG, University Hospital Bern

Enrollment

120 participants

Start Date

Jun 6, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Clinical trial investigating the chemotherapeutic compound treosulfan (Trecondi® Ideogen) in myeloma patients.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests treosulfan (a chemotherapy drug) as part of a high-dose conditioning regimen before autologous stem cell transplantation in multiple myeloma patients. The goal is to see if treosulfan is as effective (or better) than standard high-dose melphalan at preparing the body for transplant. **You may be eligible if...** - You are between 18 and 75 years old - You have multiple myeloma and have completed standard first-line induction treatment - You are fit enough to undergo high-dose chemotherapy and stem cell transplantation - Your ECOG performance score is less than 3 (meaning you are reasonably active) **You may NOT be eligible if...** - You are not considered a candidate for transplant - You have not completed induction treatment - Your overall health is too poor for high-dose chemotherapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTreosulfan

Efficacy of standard treatment melphalan will be compared to the combination melphalan with treosulfan

DRUGMelphalan

Efficacy of standard treatment melphalan will be compared to the combination melphalan with treosulfan


Locations(1)

Departement of Medical Oncology, University Hospital Berne

Bern, Switzerland

View Full Details on ClinicalTrials.gov

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NCT05636787


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