FMRI-neurofeedback in Depression

This study is testing whether a brain training technique called fMRI neurofeedback — where you learn to control your own brain activity using real-time brain scan feedback — can help reduce depression symptoms in people who haven't fully responded to antidepressants. **You may be eligible if...** - You have been diagnosed with a depressive disorder - You have been on a stable antidepressant medication for at least 4 weeks - You currently have moderate to severe depression (based on a symptom questionnaire score) **You may NOT be eligible if...** - You have a metal implant or pacemaker that makes MRI scans unsafe - You have a history of bipolar disorder, psychosis, or psychotic depression - You have used illegal drugs in the past 4 weeks - You drink alcohol excessively in a way that affects daily life - You have a neurological disease that could affect brain scan results (e.g., history of stroke) Talk to your doctor to see if this trial is right for you.