RecruitingNot ApplicableNCT05641142

Prospective Study of Antiplatelet and Anticoagulation Therapy in Hereditary Haemorrhagic Telangiectasia


Sponsor

University Hospital, Clermont-Ferrand

Enrollment

100 participants

Start Date

Apr 7, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to evaluate in real life, in patients with Hereditary Hemorrhagic Telangiectasia (HHT), the tolerance of the strategy of use of anticoagulant and/or antiplatelet, by comparing a new exposure period (first trimester of treatment) to a period of reference non-exposure (last trimester before start of treatment).


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Patient with Rendu-Osler disease with an indication of antiplatelet and/or anticoagulant introduced for less than 3 months (inclusion period within 3 months of exposure)
  • Age > 18 years old
  • Patient able to understand and agree to participate in the study
  • Affiliation to a social security system

Exclusion Criteria4

  • Patient with an indication of antiplatelet and/or anticoagulant but for whom treatment has not been introduced or introduced for more than 3 months
  • Refusal to participate
  • Pregnant woman or who are breast feeding
  • Patients under maintenance of justice, wardship or legal guardianship

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Interventions

OTHERmonitoring the use of anticoagulant and/or antiplatelet therapy in patients with osler rendering disease

Monitoring: * hemoglobin and ferritin levels * transfusion or intravenous iron * hospitalization for bleeding or thrombose * digestive bleeding and/or another haemorrhagic accident * severity of epistaxis * quality of life


Locations(18)

CHU d'Angers

Angers, France

CHU de Bordeaux

Bordeaux, France

Hôpital Ambroise Paré

Boulogne-Billancourt, France

CHU de Caen Normandie

Caen, France

CHU clermont-ferrand

Clermont-Ferrand, France

CHU de Dijon

Dijon, France

CHRU de Lille

Lille, France

Hospices Civiles de Lyon

Lyon, France

Assistance Publique - Hôpitaux de Marseille

Marseille, France

CHU de Montpellier

Montpellier, France

CHU de Nancy

Nancy, France

CHU de Nantes

Nantes, France

CHU de Nice

Nice, France

AP-HP - Hôpital Ténon

Paris, France

CHU de Poitiers

Poitiers, France

CHU de Rennes

Rennes, France

CHRU de Strasbourg

Strasbourg, France

CHU de Toulouse

Toulouse, France

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NCT05641142


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