Cholesterol Lowering and Residual Risk in Diabetes, Type 1

Inclusion Criteria11

• Participants with previous diagnosis of T1D (as defined by American Diabetes Association or judgment of physician for at least 1 year)
• American Diabetes Association Criteria for diagnosis of diabetes (Must meet at least 1 of the following criteria):
• i. FPG ≥126 mg/dL (7.0 mmol/L). Fasting is defined as no caloric intake for at least 8 hours, OR;
• ii. 2-h PG ≥200 mg/dL (11.1 mmol/L) during OGTT. The test should be performed using a glucose load containing the equivalent of 75 g anhydrous glucose dissolved in water, OR;
• iii. A1C ≥6.5% (48 mmol/mol), OR;
• iv. In a patient with classic symptoms of hyperglycemia or hyperglycemic crisis, a random plasma glucose ≥200 mg/dL (11.1 mmol/L), AND;
• History of T1D (due to autoimmune β-cell destruction, usually leading to absolute insulin deficiency, including latent autoimmune diabetes of adulthood). Autoimmune markers include islet cell autoantibodies and autoantibodies to GAD (glutamic acid decarboxylase, GAD65), insulin, the tyrosine phosphatases islet antigen 2 (IA-2) and IA-2β, and zinc transporter 8, OR;
• Diagnosis of T1D and confirmed by review of records by 2 separate clinical members of the study team
• Age ≥ 18 \& \< 90
• LDL-C \>100mg/dl
• Able and willing to provide written informed consent for the study