RecruitingNot ApplicableNCT05643859

Impact of Dietary Fiber Supplementation on Colonic Microbiome

Changes in Colonic Microbiome With Fiber Supplementation


Sponsor

OHSU Knight Cancer Institute

Enrollment

120 participants

Start Date

Apr 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial tests whether daily fiber supplementation will change the mucosal microbiome of the colon. The microbiome are microorganisms that live in the human gut. They serve a vital role in maintaining health. Certain microbial strains are associated with the growth of colon polyps, which eventually could go on to form colon cancer. Giving dietary fiber supplements may help prevent precancerous polyps from ever developing.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding dietary fiber supplements changes the types of bacteria living in the colon (the gut microbiome) in people undergoing a colonoscopy or minor surgery for benign colorectal conditions, with the goal of understanding how fiber shapes gut health. **You may be eligible if...** - You are 18 years or older - You are scheduled for a colonoscopy or minor surgery for a benign colorectal condition (such as hemorrhoids, anal fissures, or anal fistulas) - You are able to understand and sign a consent form **You may NOT be eligible if...** - You have colorectal cancer, Crohn's disease, ulcerative colitis, or a suppressed immune system - You have a hereditary colon cancer syndrome (like Lynch syndrome or FAP) - You have previously had part of your colon surgically removed - Colorectal cancer or proctitis is found during your scope Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTDietary Fiber

Given PO

PROCEDUREProctoscopy or anoscopy with Biopsy

Undergo proctoscopy or anoscopy

PROCEDUREColonoscopy

Undergo Colonoscopy

OTHERQuestionnaire Administration

Ancillary studies


Locations(1)

OHSU Knight Cancer Institute

Portland, Oregon, United States

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NCT05643859